Registration Dossier

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Not expected as harmful/toxic for fish after short-term exposures.

Key value for chemical safety assessment

Additional information

Concerning the short-term toxicity to fish potential of propiophenone, an experiment, involving five species of fish, is available from literature sources. Fish were exposed to the substance over a period of 24 hours; changes in the status (lost of equilibrium) and mortality were recorded. Under expermental conditions, the substance did not cause any death or loss of equilibrium at the tested concentration of 10 ppm (MacPhee and Ruelle, 1969). Unfortunately, many details about test method and testing procedures are lacking and it is not specified if the concentration tested have been satisfactory maintained during the experiment.

In order to deeper investigate the short-term toxicity potential, available data on the structural analogous acetophenone have been taken into account. The Read Across approach can be considered appropriate for the assessement of short-term toxicity to fish. Details can be found in the Read Across justification document attached in section 13 of IUCLID.

Both the two studies on acetophenone (Mattson et al, 1976 and Broderius and Kahl, 1985) assessed the acute toxicity to fathead minnows after an exposure period of 96 hours.

The Broderium and Kahl study was conducted according to standard procedures (ASTM, 1980), in flow-through conditions. The test item was indicated with an high grade of purity (not specified); despite details about measurements are not included into the published report, it has been stated that the test item concentrations were determined by analytical methods during the experiment. The LC50 was stated to be 236 mg/l (CL 208 -268 mg/l).

The study of Mattson et al was performed on test item at reagent-grade purity (no more details). The experiment was conducted under static conditions. The LC50 at 1 and 24 hours resulted to be higher than 200 mg/l (nominal); at 48 hrs the LC50 has been indicated to be 163 mg/l (nominal) and at 72 hours has been stated to be 158 mg/l (nominal). The LC50 at 96 hours resulted to be 155 mg/l (nominal).

A further LC50 value of 162 mg/l (no further details) and concerning acetophenone can be retrieved from secondary sources (Nendza and Wenzel, 2006).

In conclusion, based on all the available information, propiophenone is not expected to be harmful/toxic for fish after short-term exposures and at concentrations equal or lower than 100 mg/l.


Nendza, M. and Wenzel, A. 2006. Discriminating Toxicant Classes by Mode of Action 1. (Eco)toxicity Profiles. Environ Sci & Pollut Res 2006: 1 – 12.