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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Monographs on fragrance raw materials: Acetophenone.
Author:
Opdyke D.L.J
Year:
1973
Bibliographic source:
Food and Cosmetics Toxicology, 11: 99-100
Reference Type:
other: reference mentioned into the monograph
Title:
-
Author:
Kligman, A. M.
Year:
1971
Bibliographic source:
Report to RIFM, 9 June.

Materials and methods

Endpoint addressed:
skin irritation / corrosion
Principles of method if other than guideline:
Substance tested at a concentration of 2 % in petrolatum, in a 48-hr closed-patch test (25 subjects).
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Details on study design:
- Concentration: 2 % in petrolatum- Exposure period: 48-hr - Test system: closed-patch test - N. of subjects: 25 human

Results and discussion

Results:
Substance tested at a concentration of 2 % in petrolatum produced no irritation in a 48-hr closed-patch test in 25 human subjects..

Applicant's summary and conclusion

Conclusions:
The substance tested at a concentration of 2 % in petrolatum produced no irritation in a 48-hr closed-patch test in 25 human subjects.
Executive summary:

The substance tested at a concentration of 2 % in petrolatum produced no irritation in a 48-hr closed-patch test in 25 human subjects.