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Vapour pressure

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Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
Start date of the experimental work: 17/06/2009 and Completion date of the experimental work: 13/07/2009
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
unsuitable test system
Remarks:
The experimental method used for the vapour pressure determination was not suitable and the recommended range of 10+E2 to 10+E5 Pa was inappropriate for the test substance. Therefore, while the report from Chilworth Technology Ltd., (Report no. GLP102942AR1V1/09) is considered to be Klimisch 2 reliability rating it must be ignored. The second study carried out at LAUS is the suitable method for this kind of substance.
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes
Type of method:
static method
Key result
Temp.:
20 °C
Vapour pressure:
27.58 Pa
Remarks on result:
other: mean of runs 1 and 2.

Full test results:

 Temperature / °C Temperature / K   P/ mbar **P / Pa
          Run 1
 *20  293.15 0.28  27.92 
 65  338.15 300 
 80  353.15 700 
 95  368.15 12 1200 
 109  382.15 20 2000 
 126  399.15 36  3600 
          Run 2
 *20 293.15   0.27  27.24
 65 338.15  4  400
 80 353.15   7  700
 95 368.15   14  1400
 110 383.15   26  2600
 125 398.15   51  5100

* Determined by extrapolation

** Calculated

Conclusions:
Test results for the test item: 0.275 mbar (27.58 Pa) at 20°C (mean).
Executive summary:

The test is conducted according to EC 440/2008 incorporating EC’s “Classification, Packaging & Labelling of Dangerous Substances in the European Union” Part 2, Testing methods, Jan ’97. Directive 92/69, Annex V to Council Directive 67/548/EC.

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Experimental Starting date: 12 may 2010 and Experimental Completion date: 06 June 2010.
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
other: OECD 104 resp. EU A.4
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
effusion method: by loss of weight or by trapping vaporisate
Key result
Temp.:
20 °C
Vapour pressure:
0.002 Pa
Remarks on result:
other: The following estimated vapour pressures at 20°C was calculated from the regression equation.
Key result
Temp.:
25 °C
Vapour pressure:
0.004 Pa
Remarks on result:
other: The following estimated vapour pressures at 25°C was calculated from the regression equation.

The vapour pressure of MDI/MDI homopolymer/1,3-BD/TPG/PG was determined following EU A.4 by the effusion method (weight loss).

Vapour pressure at eight different temperatures was examined. Four temperatures could be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log (P).

The vapour pressure was determined at four different temperatures. 1/T was plotted a-gainst log (P).

Table: Vapour Pressures (Effusion Method)

Experiment

 T  P  Stand. Dev. P  RSD P
 No.  K  Pa  Pa  %
 4  321.5  2.55E-02  2.70E-03 10.6% 
 5 335.3   8.06E-02  1.36E-02  16.9%
 6 349.2  1.63E-01  1.50E-01  92.1%
 7 363.0  4.56E-01  7.47E-01  163.8%

In this table, E-01 represents * 10-1

The graph 1/T vs. log (P) shows a straight line with a correlation coefficient of – 0.997.

For the test item MDI/MDI homopolymer/1,3-BD/TPG/PG, the following vapour pressures at 20ºC and at 25ºC were calculated from the regression equation:

Vapour pressure at 20ºC: 2.45 * 10-03 Pa

Vapour pressure at 25ºC: 3.85 * 10-03 Pa

Conclusions:
For the test item MDI/MDI homopolymer/1,3-BD/TPG/PG, the following vapour pressures at 20°C and at 25 °C were calculated from the regression equation:

Vapour pressure at 20ºC: 2.45 * 10-03 Pa
Vapour pressure at 25ºC: 3.85 * 10-03 Pa
Executive summary:

The vapour pressure of MDI/MDI homopolymer/1,3 -BD/TPG/PG was determined following EU A.4 by effusion method (weight loss).

Vapour pressure at eight different temperatures was examined. Four temperatures could be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log (P).

the vapour pressure was determined at four different temperatures. 1/T was plotted against log (P).

 Experiemnt Standard Deviation P  RSD P 
 N° Pa  Pa 
 4  321.5  2.55E-02   2.70E-03  10.6%
 5 335.3   8.06E-02  1.36E-02  16.95
 6 349.2  1.63E-01  1.50E-01  92.1%
 7  363.0  4.56E-01  7.47E-01  163.8%

The graph 1/T vs. log(P) shows a straight line with a correlation coefficient of -0.997.

For the test item MDI/MDI homopolymer/1,3 -BD/TPG/PG, the following vapour pressures at 20°C and 25°C were calculated from the regression equation:

Vapour pressure at 20ºC:       2.45 * 10-03 Pa

Vapour pressure at 25ºC:       3.85 * 10-03 Pa

Description of key information

The experimental method used at Chilworth Technology Ltd. for vapour pressure determination was not suitable and the recommended ranges were inappropriate. Therefore, the study from Chilworth Technology Ltd., is considered to be Klimisch 3 reliability rating and it must be ignored.
The following estimated vapour pressures at 20°C and at 25°C were calculated from the regression equation:
Vapour pressure at 20°C: 2.45 * 10-03 Pa
Vapour pressure at 25°C: 3.85 * 10-03 Pa

Key value for chemical safety assessment

Additional information