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EC number: 202-548-8 | CAS number: 96-97-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The substance 5-nitrosalicylic acid does not exhibit repeated dose toxicity by oral,inhalation and dermal route.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- 452.16 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- The data is K2 level as the data has been obtained from QSAR model considered by OECD.
Repeated dose toxicity: inhalation - systemic effects
Link to relevant study records
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: Estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 3.1
- GLP compliance:
- no
- Species:
- mouse
- Strain:
- B6C3F1
- Sex:
- male/female
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 90 days
- Control animals:
- not specified
- Dose descriptor:
- LOEL
- Effect level:
- 19.56 other: mg/kg/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: not specified
- Remarks on result:
- other: not specified
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Conclusions:
- The repeated dose toxicity LOEL (Low observed effect level) of 5-nitrosalicylic acid to mouse by the inhalation route was estimated at a dose concentration of 19.56 mg/kg bw/day.On the basis of this LOEL value it is concluded that the test substance is not toxic to mouse by the inhalative route below the above mentioned dose.
- Executive summary:
The repeated dose toxicity LOEL (Low observed effect level) of 5-nitrosalicylic acid to mouse by the inhalation route was estimated at a dose concentration of 19.56 mg/kg bw/day.On the basis of this LOEL value it is concluded that the test substance is not toxic to mouse by the inhalative route below the above mentioned dose.
Reference
The
prediction was based on dataset comprised from the following
descriptors: "study LOEL"
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((((("a"
and "b" )
and "c" )
and "d" )
and "e" )
and ("f"
and "g" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Group 14 - Carbon C AND Group 15
- Nitrogen N AND Group 16 - Oxygen O by Chemical elements
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Bioavailable by Lipinski Rule
Oasis
Domain
logical expression index: "c"
Similarity
boundary:Target:
C(=O)(O)c1c(O)ccc(N(=O)=O)c1
Threshold=10%,
Dice(Atom centered fragments)
Domain
logical expression index: "d"
Similarity
boundary:Target:
C(=O)(O)c1c(O)ccc(N(=O)=O)c1
Threshold=20%,
Dice(Atom centered fragments)
Domain
logical expression index: "e"
Similarity
boundary:Target:
C(=O)(O)c1c(O)ccc(N(=O)=O)c1
Threshold=30%,
Dice(Atom centered fragments)
Domain
logical expression index: "f"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 1.81
Domain
logical expression index: "g"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 3.1
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- 19.56 mg/m³
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- The data is K2 level as the data has been obtained from QSAR model considered by OECD.
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Link to relevant study records
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 410 (Repeated Dose Dermal Toxicity: 21/28-Day Study)
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Type of coverage:
- semiocclusive
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 28 days
- Control animals:
- not specified
- Dose descriptor:
- NOAEL
- Effect level:
- 766.666 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: not specified
- Remarks on result:
- other: not specified
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Conclusions:
- The repeated dose toxicity NOAEL (No observed adverse effect level) of 5-nitrosalicylic acid to rabbit by the dermal route was estimated at a dose concentration of 766.666 mg/kg bw/day.On the basis of this NOAEL value it is concluded that the test substance is not toxic to rabbit by the dermal
route. - Executive summary:
The repeated dose toxicity NOAEL (No observed adverse effect level) of 5-nitrosalicylic acid to rabbit by the dermal route was estimated at a dose concentration of 766.666 mg/kg bw/day.On the basis of this NOAEL value it is concluded that the test substance is not toxic to rabbit by the dermal route.
Reference
The
prediction was based on dataset comprised from the following
descriptors: NOAEL
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
("a"
and ("b"
and "c" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Group 14 - Carbon C AND Group 15
- Nitrogen N AND Group 16 - Oxygen O by Chemical elements
Domain
logical expression index: "b"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -10.1
Domain
logical expression index: "c"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 2.69
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 766.666 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rabbit
- Quality of whole database:
- The data is K2 level as the data has been obtained from QSAR model considered by OECD.
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Repeated dose toxicity: oral
The repeated dose toxicity LOEL (Lowest observed effect level) of 5-nitrosalicylic acid to rat by the oral (Feed) route was estimated at a dose concentration of 452.16 mg/kg bw/day.On the basis of this LOEL value it is concluded that the test substance is not toxic to rat by the oral route below the above mentioned dose.
Repeated dose toxicity: inhalation
The repeated dose toxicity LOEL (Low observed effect level) of 5-nitrosalicylic acid to mouse by the inhalation route was estimated at a dose concentration of 19.56 mg/kg bw/day.On the basis of this LOEL value it is concluded that the test substance is not toxic to mouse by the inhalative route below the above mentioned dose.
Repeated dose toxicity: dermal
The repeated dose toxicity NOAEL (No observed adverse effect level) of 5-nitrosalicylic acid to rabbit by the dermal route was estimated at a dose concentration of 766.666 mg/kg bw/day.On the basis of this NOAEL value it is concluded that the test substance is not toxic to rabbit by the dermal route.
Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
The repeated dose toxicity LOEL (Lowest observed effect level) of 5-nitrosalicylic acid to rat by the oral (Feed) route was estimated at a dose concentration of 452.16 mg/kg bw/day.On the basis of this LOEL value it is concluded that the test substance is not toxic to rat by the oral route below the above mentioned dose.
Justification for selection of repeated dose toxicity inhalation - systemic effects endpoint:
The repeated dose toxicity LOEL (Low observed effect level) of 5-nitrosalicylic acid to mouse by the inhalation route was estimated at a dose concentration of 19.56 mg/kg bw/day.On the basis of this LOEL value it is concluded that the test substance is not toxic to mouse by the inhalative route below the above mentioned dose.
Justification for selection of repeated dose toxicity dermal - systemic effects endpoint:
The repeated dose toxicity NOAEL (No observed adverse effect level) of 5-nitrosalicylic acid to rabbit by the dermal route was estimated at a dose concentration of 766.666 mg/kg bw/day.On the basis of this NOAEL value it is concluded that the test substance is not toxic to rabbit by the dermal
route.
Justification for classification or non-classification
The substance 5-nitrosalicylic acid do not show repeated dose toxicity effect for oral,dermal and inhalation route and thus will not be considered for further classification.
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