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EC number: 202-548-8 | CAS number: 96-97-9
Endpoint summary
Administrative data
Description of key information
The substance 5-nitrosalicylic acid does not showed toxicity effect by oral,dermal and inhalation route within the dose levels mentioned in the respective end points.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- No. of animals per sex per dose:
- 6 animals
- Control animals:
- not specified
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- 2 400 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (approx. LD50) of 5-nitrosalicylic acid in rat was found to be 2400 mg/kg of body weight. Acute toxicity of 5-nitrosalicylic acid to male and female rat indicates that 5-nitrosalicylic acid does not exhibits acute toxicity by the oral route within above mention dose.
- Executive summary:
The acute oral median lethal dose (approx. LD50) of 5-nitrosalicylic acid in rat was found to be 2400 mg/kg of body weight. Acute toxicity of 5-nitrosalicylic acid to male and female rat indicates that 5-nitrosalicylic acid does not exhibits acute toxicity by the oral route within above mention dose.
Reference
The prediction was based on dataset comprised from the following descriptors: "approx. LD50"
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(((("a" and ("b" and ( not "c") ) ) and "d" ) and "e" ) and ("f" and "g" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Group 14 - Carbon C AND Group 15 - Nitrogen N AND Group 16 - Oxygen O by Chemical elements
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Not possible to classify according to these rules (GSH) by Protein binding potency
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Moderately reactive (GSH) OR Moderately reactive (GSH) >> 2-Vinyl carboxamides (MA) by Protein binding potency
Domain logical expression index: "d"
Referential boundary: The target chemical should be classified as No superfragment by Superfragments
Domain logical expression index: "e"
Similarity boundary:Target: C(=O)(O)c1c(O)ccc(N(=O)=O)c1
Threshold=10%,
Dice(Atom centered fragments)
Domain logical expression index: "f"
Parametric boundary:The target chemical should have a value of log Kow which is >= -2.29
Domain logical expression index: "g"
Parametric boundary:The target chemical should have a value of log Kow which is <= 4.23
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 400 mg/kg bw
- Quality of whole database:
- The data is K2 level as the data has been obtained from QSAR model considered by OECD.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose only
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- No. of animals per sex per dose:
- 6 animals
- Control animals:
- not specified
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 1 255 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The 4 hrs acute inhalation median lethal concentration (LC50) of 5-nitrosalicylic acid in rat was found to be 1255mg/L.Acute toxicity of 5-nitrosalicylic acid to rat by the inhalation route indicates that 5-nitrosalicylic acid does not exhibits acute toxicity by the inhalative route within the doses mentioned.
- Executive summary:
The 4 hrs acute inhalation median lethal concentration (LC50) of 5-nitrosalicylic acid in rat was found to be 1255mg/L.Acute toxicity of 5-nitrosalicylic acid to rat by the inhalation route indicates that 5-nitrosalicylic acid does not exhibits acute toxicity by the inhalative route within the doses mentioned.
Reference
The prediction was based on dataset comprised from the following descriptors: LC50
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(((("a" and ("b" and ( not "c") ) ) and "d" ) and "e" ) and ("f" and "g" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Group 14 - Carbon C AND Group 15 - Nitrogen N AND Group 16 - Oxygen O by Chemical elements
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Group 14 - Carbon C AND Group 15 - Nitrogen N AND Group 16 - Oxygen O by Chemical elements
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Group 16 - Sulfur S OR Group 17 - Halogens Cl OR Group 17 - Halogens F OR Group 17 - Halogens F,Cl,Br,I,At by Chemical elements
Domain logical expression index: "d"
Referential boundary: The target chemical should be classified as Bioavailable by Lipinski Rule Oasis
Domain logical expression index: "e"
Similarity boundary:Target: C(=O)(O)c1c(O)ccc(N(=O)=O)c1
Threshold=10%,
Dice(Atom centered fragments)
Domain logical expression index: "f"
Parametric boundary:The target chemical should have a value of log Kow which is >= 2.36
Domain logical expression index: "g"
Parametric boundary:The target chemical should have a value of log Kow which is <= 4.37
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 1 255 mg/m³ air
- Quality of whole database:
- The data is K2 level as the data has been obtained from QSAR model considered by OECD.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Control animals:
- not specified
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 9 862.85 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal median lethal concentration (LC50) of 5-nitrosalicylic acid in rabbit was found to be 9862.85 mg/L.Acute toxicity of 5-nitrosalicylic acid to rabbit by the dermal route indicates that 5-nitrosalicylic acid does not exhibits acute toxicity by the dermal route within the doses mentioned.
- Executive summary:
The acute dermal median lethal concentration (LC50) of 5-nitrosalicylic acid in rabbit was found to be 9862.85 mg/L.Acute toxicity of 5-nitrosalicylic acid to rabbit by the dermal route indicates that 5-nitrosalicylic acid does not exhibits acute toxicity by the dermal route within the doses mentioned.
Reference
The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Takes average value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
((((("a" and ("b" and ( not "c") ) ) and "d" ) and "e" ) and "f" ) and ("g" and "h" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Group 14 - Carbon C AND Group 15 - Nitrogen N AND Group 16 - Oxygen O by Chemical elements
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Group 14 - Carbon C AND Group 15 - Nitrogen N AND Group 16 - Oxygen O by Chemical elements
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Group 1 - Alkali Earth Li,Na,K,Rb,Cs,Fr OR Group 14 - Metalloids Si,Ge OR Group 15 - Phosphorus P OR Group 16 - Sulfur S OR Group 17 - Halogens Cl OR Group 17 - Halogens F OR Group 17 - Halogens F,Cl,Br,I,At by Chemical elements
Domain logical expression index: "d"
Similarity boundary:Target: C(=O)(O)c1c(O)ccc(N(=O)=O)c1
Threshold=10%,
Dice(Atom centered fragments)
Domain logical expression index: "e"
Similarity boundary:Target: C(=O)(O)c1c(O)ccc(N(=O)=O)c1
Threshold=20%,
Dice(Atom centered fragments)
Domain logical expression index: "f"
Similarity boundary:Target: C(=O)(O)c1c(O)ccc(N(=O)=O)c1
Threshold=30%,
Dice(Atom centered fragments)
Domain logical expression index: "g"
Parametric boundary:The target chemical should have a value of log Kow which is >= 1.03
Domain logical expression index: "h"
Parametric boundary:The target chemical should have a value of log Kow which is <= 3.74
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 9 862.85 mg/kg bw
- Quality of whole database:
- The data is K2 level as the data has been obtained from QSAR model considered by OECD.
Additional information
Acute toxicity: oral
The acute oral median lethal dose (approx. LD50) of 5-nitrosalicylic acid in rat was found to be 2400 mg/kg of body weight. Acute toxicity of 5-nitrosalicylic acid to male and female rat indicates that 5-nitrosalicylic acid does not exhibits acute toxicity by the oral route within above mention dose.
Acute toxicity: inhalation
The 4 hrs acute inhalation median lethal concentration (LC50) of 5-nitrosalicylic acid in rat was found to be 1255mg/L.Acute toxicity of 5-nitrosalicylic acid to rat by the inhalation route indicates that 5-nitrosalicylic acid does not exhibits acute toxicity by the inhalative route within the doses mentioned.
Acute toxicity: dermal
The acute dermal median lethal concentration (LC50) of 5-nitrosalicylic acid in rabbit was found to be 9862.85 mg/L.Acute toxicity of 5-nitrosalicylic acid to rabbit by the dermal route indicates that 5-nitrosalicylic acid does not exhibits acute toxicity by the dermal route within the doses mentioned.
Justification for selection of acute toxicity – oral endpoint
The acute oral median lethal dose (approx. LD50) of 5-nitrosalicylic acid in rat was found to be 2400 mg/kg of body weight. Acute toxicity of 5-nitrosalicylic acid to male and female rat indicates that 5-nitrosalicylic acid does not exhibits acute toxicity by the oral route within above mention dose.
Justification for selection of acute toxicity – inhalation endpoint
The 4 hrs acute inhalation median lethal concentration (LC50) of 5-nitrosalicylic acid in rat was found to be 1255mg/L.Acute toxicity of 5-nitrosalicylic acid to rat by the inhalation route indicates that 5-nitrosalicylic acid does not exhibits acute toxicity by the inhalative route within the doses mentioned.
Justification for selection of acute toxicity – dermal endpoint
The acute dermal median lethal concentration (LC50) of 5-nitrosalicylic acid in rabbit was found to be 9862.85 mg/L.Acute toxicity of 5-nitrosalicylic acid to rabbit by the dermal route indicates that 5-nitrosalicylic acid does not exhibits acute toxicity by the dermal route within the doses mentioned.
Justification for classification or non-classification
The substance 5-nitrosalicylic acid is not classified as per the C & L criteria set by EU.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
