Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Based upon the physico-chemical and bio-accumulative preperties, information on the most likely behaviour of the chemical 5-nitrosalicylic acid upon absorption into the living system, distribution and excretion has been provided. From the available information, it is assumed that the chemical will not be bio-accumulative

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

Details on absorption

Considering the use of 5-nitrosalicylic acid, as a dye and medicinal intermediate; the most likely route of exposure is expected to be dermal. However, considering that in an industrial environment the use of gloves is prevalent, dermal absorption shall be limited.

Details on distribution in tissues

5-nitrosalicylic acid is soluble in water as well as methanol. Thus, it is highly likely that this substance, if absorbed is likely to be distributed to the other parts of the living system through the blood and lipids. But given its low bio-concentration factor (BCF) of 3.2, 5-nitrosalicylic acid shall not bio-accumulate in the living system and is likely to be excreted out of the body.

Details on excretion

5-nitrosalicylic acid is soluble in water as well as methanol. Thus, it is highly likely that this substance, if absorbed is likely to be distributed to the other parts of the living system through the blood and lipids. But given its low bio-concentration factor (BCF) of 3.2, 3-oxoglutaric acid shall not bio-accumulate in the living system. As a general rule, the chemicals that do not bio-accumulate are likely to be excreted out of the body either through urine, bile or faeces.