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Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other:
Title:
Estimation for study LOEL for CAS 96-97-9
Author:
Sustainability Support Services (Europe) AB
Year:
2013
Bibliographic source:
QSAR Toolbox version 3.1

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Estimated data
Principles of method if other than guideline:
Prediction is done using QSAR Toolbox version 3.1
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
5-nitrosalicylic acid
EC Number:
202-548-8
EC Name:
5-nitrosalicylic acid
Cas Number:
96-97-9
Molecular formula:
C7H5NO5
IUPAC Name:
5-nitrosalicylic acid
Details on test material:
- Name of test material (as cited in study report): 5-nitrosalicylic acid
- Substance type: Organic
- Physical state: solid

Test animals

Species:
mouse
Strain:
B6C3F1
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
90 days
Control animals:
not specified

Results and discussion

Effect levels

Dose descriptor:
LOEL
Effect level:
19.56 other: mg/kg/day
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: not specified
Remarks on result:
other: not specified

Target system / organ toxicity

Critical effects observed:
not specified
System:
other: not specified
Organ:
not specified

Any other information on results incl. tables

The prediction was based on dataset comprised from the following descriptors: "study LOEL"
Estimation method: Takes average value from the 5 nearest neighbours
Domain  logical expression:Result: In Domain

((((("a" and "b" )  and "c" )  and "d" )  and "e" )  and ("f" and "g" )  )

Domain logical expression index: "a"

Referential boundary: The target chemical should be classified as Group 14 - Carbon C AND Group 15 - Nitrogen N AND Group 16 - Oxygen O by Chemical elements

Domain logical expression index: "b"

Referential boundary: The target chemical should be classified as Bioavailable by Lipinski Rule Oasis

Domain logical expression index: "c"

Similarity boundary:Target: C(=O)(O)c1c(O)ccc(N(=O)=O)c1
Threshold=10%,
Dice(Atom centered fragments)

Domain logical expression index: "d"

Similarity boundary:Target: C(=O)(O)c1c(O)ccc(N(=O)=O)c1
Threshold=20%,
Dice(Atom centered fragments)

Domain logical expression index: "e"

Similarity boundary:Target: C(=O)(O)c1c(O)ccc(N(=O)=O)c1
Threshold=30%,
Dice(Atom centered fragments)

Domain logical expression index: "f"

Parametric boundary:The target chemical should have a value of log Kow which is >= 1.81

Domain logical expression index: "g"

Parametric boundary:The target chemical should have a value of log Kow which is <= 3.1

Applicant's summary and conclusion

Conclusions:
The repeated dose toxicity LOEL (Low observed effect level) of 5-nitrosalicylic acid to mouse by the inhalation route was estimated at a dose concentration of 19.56 mg/kg bw/day.On the basis of this LOEL value it is concluded that the test substance is not toxic to mouse by the inhalative route below the above mentioned dose.
Executive summary:

The repeated dose toxicity LOEL (Low observed effect level) of 5-nitrosalicylic acid to mouse by the inhalation route was estimated at a dose concentration of 19.56 mg/kg bw/day.On the basis of this LOEL value it is concluded that the test substance is not toxic to mouse by the inhalative route below the above mentioned dose.