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Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
data is from NTRL reports

Data source

Reference
Reference Type:
secondary source
Title:
Initial Submission: Toxicological Investigation of Silester A-1 with Cover Letter dated 072392
Author:
MONSANTO COMPANY
Year:
1992
Bibliographic source:
EPA TSCATS Summary , MONSANTO COMPANY, last updated 072392

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the dermal irritation potential of the test chemical
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Silicic acid, ethyl ester
EC Number:
234-324-0
EC Name:
Silicic acid, ethyl ester
Cas Number:
11099-06-2
Molecular formula:
C2 H6 O.x-Unspecified
IUPAC Name:
Silicic acid, ethyl ester
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): Silicic acid, ethyl ester
- IUPAC name: ethoxy(oxo)silanol
- Molecular formula: C2H6O.x-Unspecified
- Molecular weight: 208.328 g/mol
- Smiles notation: [Si](OCC)(OCC)(OCC)OCC
- Substance type: Organic
- Physical state: liquid (clear colourless solution)

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
Sex: Male and Female

Test system

Type of coverage:
other: dermal
Preparation of test site:
other: no data available
Vehicle:
other: no data available
Controls:
not specified
Amount / concentration applied:
no data available
Duration of treatment / exposure:
1 hour till 7 days
Observation period:
1 hour till 7 days
Number of animals:
2 male and 1 female
Details on study design:
no data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 1 hour till 7 days
Score:
0
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No irritation observed
Other effects:
no data available

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
No Primary Dermal Irritation was noted in 2 males and 1 female rabbits at any time from 1 hour till 7 days.
Hence,the test chemical can be considered not irritating to skin.
Executive summary:

A Primary Dermal Irritation study was performed on rabbits to assess the irritation potential of the test chemical.2 male and 1 female rabbits were used for the study. The test chemical was applied on the skin of rabbits and the effects were observed from 1 hour after application till day 7.

No Primary Dermal Irritation was noted in rabbits at any time from 1 hour till 7 days.

Hence,the test chemical can be considered not irritating to skin.