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EC number: 234-324-0 | CAS number: 11099-06-2
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on three hydrolysis studies as-
2. and 3. - GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Analytical monitoring:
- not specified
- Remarks:
- 2. The study was performed at temp. 10, 25 & 35°C and pH 4, 7 & 9, respectively.
- Remarks:
- 3. Other details not known
- Positive controls:
- not specified
- Negative controls:
- not specified
- Transformation products:
- not specified
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- 0.11 h
- Remarks on result:
- other: 2. Other details not known
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 4.4 h
- Remarks on result:
- other: 2. Other details not known
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- 0.22 h
- Remarks on result:
- other: 2. Other details not known
- Remarks on result:
- other: 3. Test chemical is reported to be hydrolysable in water.
- Details on results:
- 2. The hydrolysis of test chemical was observed to follow pseudo first-order kinetics, was pH dependent and increased as a function of temperature. The half-life of test chemical at 25 °C was observed to be 0.11, 4.4, and 0.22 hrs at pH 4, 7, and 9, respectively. At 10 °C, the half-life of test chemical was observed to be 0.20 and 0.76 hrs at pH 4 and 9, respectively. At 35°C, the half-life of test chemical was observed to be 0.073 and 0.12 hrs at pH 4 and 9, respectively.
3. Test chemical is reported to be hydrolysable in water after a period of 2 days. - Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be 4.4 hrs at a temperature range of 25°C and pH 7.0, respectively. Thus, based on this half-life value, it can be concluded that the test chemical can be considered to be moderately hydrolysable in water.
- Executive summary:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical.The studies are as mentioned below:
The half-life of the test chemical was determined.The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH). The study was performed at temp. 10, 25 and 35°C and pH 4, 7 and 9, respectively. Test chemical hydrolysis was followed by measuring its disappearance as a function of time by an extraction method using gas chromatography with flame ionization detection (GC-FID). The half-life of test chemical at 25 °C was observed to be 0.11, 4.4, and 0.22 hrs at pH 4, 7, and 9, respectively. At 10 °C, the half-life of test chemical was observed to be 0.20 and 0.76 hrs at pH 4 and 9, respectively. At 35°C, the half-life of test chemical was observed to be 0.073 and 0.12 hrs at pH 4 and 9, respectively. Thus, based on the half-life value (4.4 hrs) at temp. 25 °C and pH 7.0, test chemical is considered to be moderately hydrolysable in water.
In an another study, the half-life of the test chemical was determined. Although half-life value of test chemical was not known, but test chemical was reported to be hydrolysable in water after a period of 2 days.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be 4.4 hrs at a temperature range of 25°C and pH 7.0, respectively. Thus, based on this half-life value, it can be concluded that the test chemical can be considered to be moderately hydrolysable in water.
Reference
Description of key information
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be 4.4 hrs at a temperature range of 25°C and pH 7.0, respectively. Thus, based on this half-life value, it can be concluded that the test chemical can be considered to be moderately hydrolysable in water.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 4.4 h
- at the temperature of:
- 25 °C
Additional information
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:
The half-life of the test chemical was determined. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH). The study was performed at temp. 10, 25 and 35°C and pH 4, 7 and 9, respectively. Test chemical hydrolysis was followed by measuring its disappearance as a function of time by an extraction method using gas chromatography with flame ionization detection (GC-FID). The half-life of test chemical at 25 °C was observed to be 0.11, 4.4, and 0.22 hrs at pH 4, 7, and 9, respectively. At 10 °C, the half-life of test chemical was observed to be 0.20 and 0.76 hrs at pH 4 and 9, respectively. At 35°C, the half-life of test chemical was observed to be 0.073 and 0.12 hrs at pH 4 and 9, respectively. Thus, based on the half-life value (4.4 hrs) at temp. 25 °C and pH 7.0, test chemical is considered to be moderately hydrolysable in water.
In an another study, the half-life of the test chemical was determined. Although half-life value of test chemical was not known, but test chemical was reported to be hydrolysable in water after a period of 2 days.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be 4.4 hrs at a temperature range of 25°C and pH 7.0, respectively. Thus, based on this half-life value, it can be concluded that the test chemical can be considered to be moderately hydrolysable in water.
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