Silicic acid, ethyl ester

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard OECD test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

GLP compliance:

no

Type of method:

flask method

Key result

Water solubility:

16.662 mg/L

Conc. based on:

test mat.

Temp.:

25 °C

Remarks on result:

other: other details not mentioned

WATER SOLUBILITY: PRELIMINARY TEST

0.1g of test item was taken in 100 ml beaker. DI water was added in increasing amount in sequence of 0.1 ml, 0.5 ml, 1.0 ml,

2.0 ml, 10.0 ml and 100.0 ml with intermediate stirring.

For poorly soluble substances: Preliminary water solubility of test item was found 0.1 g in > 100 ml DI water. For analytical

determination 100 mg of test item was dissolved in 100 ml of DI water. The solution was kept for 24 hrs on stirring and absorbance was recorded. Concentration detected on the basis of standard curve was 20.557 mg/L. Five times the concentration recorded from preliminary solubility was used for confirmatory study.

WATER SOLUBILITY: CONFIRMATORY TEST

Five times the concentration recorded from preliminary solubility = 20.557 mg/L × 5 = 102.785 mg/L was used for confirmatory

study. Two separate solution of 10.2785 mg in 100 ml DI water were prepared and kept for stirring for 48 hrs and 72 hrs. After

the completion of stirring period the absorbance for all the two solution were recorded and concentration was detected on the

basis of standard curve. Table 2 refers to the same.

Sample stirring	Concentration obtained on the basis of standard curve	Dilution factor	Solubility value obtained (mg/L)
24 hour	-	-	-
48 hour	16.8099	-	16.8099
72 hour	16.5142	-	16.5142

 

Considering the water solubility for 48 hrs and 72 hrs the mean water solubility was calculated as follows: Mean water solubility value for 48 hour run sample + 72 hour run sample

=(16.8099+16.5142)/2

=16.6621 mg/L

Conclusions:

The water solubility for the test chemical was determined to be 16.6621 mg/L at 25°C.

Executive summary:

The water solubility determination of test chemical was done as per the OECD guideline 105 and by spectrophotometric analytical method as per OECD 101. The solubility of test chemical in water was determined to be 16.6621 mg/L at 25°C.

Hence on the basis of experimental value the given substance is considered to be slightly soluble in water.

Description of key information

The solubility of test chemical in water was determined to be 16.6621 mg/L at 25°C.

Key value for chemical safety assessment

Water solubility:

16.662 mg/L

at the temperature of:

25 °C

Additional information

The water solubility determination of test chemical was done as per the OECD guideline 105 and by spectrophotometric analytical method as per OECD 101. The solubility of test chemical in water was determined to be 16.6621 mg/L at 25°C.

Hence on the basis of experimental value the given substance is considered to be slightly soluble in water.

On the basis of data obtained from authoritative database, test chemical was reported to be soluble in water.