Registration Dossier
Registration Dossier
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EC number: 234-324-0 | CAS number: 11099-06-2
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Estimation Programs Interface Suite (2018) was run to predict the biodegradation potential of the test chemical in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that test chemical is expected to be not readily biodegradable.
Additional information
Biodegradation in water
Predicted data for the test chemical and supporting study for its read across substance were reviewed for the biodegradation end point which are summarized as below:
In a prediction using the Estimation Programs Interface Suite (2018), the biodegradation potential of the test chemicalin the presence of mixed populations of environmental microorganisms was estimated. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that test chemical is expected to be not readily biodegradable.
For the test chemical, biodegradation study was conducted for 29 days for evaluating the percentage biodegradability of test chemical (Secondary source, 2008). The study was performed according to EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test). Initial test substance conc. used in the study was 39.1 mg/l. Activated sludge, domestic was used as a test inoculum. Inoculum was a living slime from a primary communal sewage treatment plant (Marl-East). Mineral medium and inoculum were placed into the test containers and the test chemical or positive control was introduced. The test containers were sealed and incubated at 20.8 - 22.1 deg C and shaken at approximately 180 rpm. An hour before analysis, sodium hydroxide is added, respectively, to each bottle. The sodium hydroxide is sufficient to absorb the CO2 that is evolved when the test chemical is completely degraded. The degree of biodegradation was recorded on day 0, 1, 4, 8, 13, 18, 21, 26, 28 and 29. The control substance achieved a breakdown rate of 76% within 10 days after an initial exceedance of the 10% breakdown threshold. The percentage degradation of test chemical was determined to be 47% by CO2 evolution parameter in 28 days. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.
On the basis of above results for test chemical, it can be concluded that the test chemical can be expected to be not readily biodegradable in nature.
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