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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Publication, reasonably documented, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Potential of the rat as a model for predicting iron bioavailability for humans.
Author:
Mahoney AW, Hendricks DG
Year:
1984
Bibliographic source:
DOI 10.1016/S0271-5317(84)80067-6 ISSN 0271-5317 Nutrition Res 4(5):913-22.

Materials and methods

Principles of method if other than guideline:
Iron salt species analysed: unclear

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Results and discussion

Main ADME results
Type:
other: bioavailability
Results:
The amount of iron absorbed by people and animals varies directly with their iron status. The average human response is 68 % that by the rats.

Any other information on results incl. tables

Justification for read-across

The surrogate material dissociates in physiological pH to the same species produced by the (iron III & II) salts after equilibration. As discussed in the category justification section, such equilibrium is quickly established. In result, iron species burden is assumed to be comparable to equimolar exposure within the iron category member salts.

Applicant's summary and conclusion