Registration Dossier

Toxicological information

Sensitisation data (human)

Currently viewing:

Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Epidermal hypersensitivity to iron. [Article in German]
Author:
Nater JP
Year:
1960
Bibliographic source:
PMID 13727904 ISSN 0017-8470 Hautarzt 11(May):223-4

Materials and methods

Type of sensitisation studied:
skin
Study type:
case report
Test guideline
Qualifier:
no guideline followed

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Results of examinations:
Case report of an incidence of sensitisation to ferric chloride and ferric sulphate. A 44 year old male presented with eczema-type reactions on his skin in areas that were exposed to steel particles during his job using high pressure cleaning equipment to remove steel particles from construction elements. An initial patch test using steel particles resulted in erythema after 48 hours. The reaction had increased at 72 hours. Further tests were carried out. The substances tested and the results are tabulated below. These tests were repeated three times with identical results. About 30 people were used for the control test.

Substance 48 hours 72 hours
zinc sulphate 5% - -
ammonium molybdate 1% - -
calcium chromate 0.5% - -
calcium dichromate 0.5% - -
chromium sulphate 2% - -
chromium chloride 2% - -
aluminium chloride 2% - -
aluminium vanadate 1% - -
cobalt chloride 2% - -
nickel sulphate 5% - -
copper sulphate 5% - -
sheet iron - -
nickel coated plate - -
chromium coated plate - -
ferrous tartrate,
saturated - -
ferrous sulphate 10% - -
ferric chloride 0.1% - -
ferric chloride 1% - +
ferric chloride 2% - +++
ferric sulphate 10% - ++

The authors concluded that very close contact with the metal had resulted in sensitisation to ferric compounds in this individual.

Applicant's summary and conclusion

Conclusions:
Case report of an incidence of sensitisation to ferric chloride and ferric sulphate. A 44 year old male presented with eczema-type reactions on his skin in areas that were exposed to steel particles during his job using high pressure cleaning equipment to remove steel particles from construction elements. The authors concluded that very close contact with the metal had resulted in sensitisation to ferric compounds in this individual.