Registration Dossier

Toxicological information

Health surveillance data

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Administrative data

Endpoint:
health surveillance data
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
A Fatal case of acute ferric chloride poisoning.
Author:
Ling W, Chen-Chang Y, Jiin G, Jou-Fang D
Year:
1988
Bibliographic source:
PMID 9467207 Vet Human Toxicol 40(1):31-4.

Materials and methods

Study type:
human medical data
Endpoint addressed:
acute toxicity: oral

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Results:
A 25 year old woman fatally ingested 200 mL ferric chloride solution (pH 1), equivalent to 230 mg/kg bw of elemental iron. She had hypoxemia and severe metabolic acidosis with respiratory alkalosis initially. Three hours after her ingestion she presented with drowsy consciousness, tachycardia, tachypnea and projected vomiting. Laboratory studies showed leukocytosis, elevated glucose, aspartate aminotransferase, amylase, lactate dehydrogenase and total bilirubin, coagulation defect and haemolysis. Aspiration and vision loss were also reported. Four hours after ingestion cardiopulmonary arrest suddenly occurred after severe vomiting and the woman died. Toxicological studies showed marked elevation of serum iron (2440 µg/dL).

Applicant's summary and conclusion