Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Reaction product of 2-hydroxybenzoic acid, styrene and oxozinc
- Molecular formula:
- not applicable for UVCB substance
- IUPAC Name:
- Reaction product of 2-hydroxybenzoic acid, styrene and oxozinc
- Test material form:
- liquid - solid: mixture of
- Remarks:
- water and Reaction products of 2-hydroxybenzoic acid and styrene and zinc oxide
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL of test material
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 3 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure:
6 cm*cm
REMOVAL OF TEST SUBSTANCE
- Washing (if done): using water
- Time after start of exposure: 4 hours
OBSERVATION TIME POINTS
1 h, 24 h , 48 h and 72 h
SCORING SYSTEM:
- Method of calculation:
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Accoding to the results of Acute dermal irritation/Corrosion study, the test item was consiered as non- skin irritation.
- Executive summary:
In the acute dermal irritation/Corrosion study according to OECD TG 404, three male adult albino rabbits(New Zealand strain） were applied with 0.5 mL Reaction Product of 2-Hydroxybenzoic Acid, Styrene and Oxozinc for 4 hours by a semi-occlusive exposure.There was no erythema or oedema or any other changed induced, and the score of erythema and oedema were equal to 0.Therefore, the test item was consiered as non- skin irritation.
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