Reaction product of 2-hydroxybenzoic acid, styrene and oxozinc

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2002

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2002

Report date:

2002

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

GLP compliance:

not specified

Test type:

fixed concentration procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Reaction product of 2-hydroxybenzoic acid, styrene and oxozinc

Molecular formula:

not applicable for UVCB substance

IUPAC Name:

Reaction product of 2-hydroxybenzoic acid, styrene and oxozinc

Test material form:

liquid - solid: mixture of

Remarks:

water and Reaction products of 2-hydroxybenzoic acid and styrene and zinc oxide

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Center of Experimental Animals,AMMS,Beijing
- Weight at study initiation: 180-220 g
- Acclimation period: 5 days


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22-26°C
- Humidity (%): 40-60%
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

not specified

Vehicle:

water

Mass median aerodynamic diameter (MMAD):

< 1 µm

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Temperature:20-24℃
- Humidity:100%
- Air flow rate: 0.8 m3/hr


TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: smaller than 1μm

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

5 h

Concentrations:

5 mg/L

No. of animals per sex per dose:

10

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 5 mg/L air

Based on:

test mat.

Exp. duration:

5 h

Mortality:

No animal died during the study.

Clinical signs:

other: No clinical signs observed during the study.

Body weight:

Body weight increased

Gross pathology:

No pathological changes were observed at necropsy.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The inhalation LC50 of test item was greater than 5 mg/L for both male and female Wistar rats.

Executive summary:

In an acute inhalation toxicity study according to OECD TG 403,  10 male and 10 female Wistar rats were exposed to test item at the dose level of 5 mg/L for 5 hours and afterwards observed for 14 days after removal of the test item.No clinical toxic signs were observed after application of test item and no death occurred with two weeks.No pathological changes were observed at necropsy.Inhalation LD50 was determined as larger than 5 mg/L for both male and female Wistar rats.