Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction product of 2-hydroxybenzoic acid, styrene and oxozinc
- Molecular formula:
- not applicable for UVCB substance
- IUPAC Name:
- Reaction product of 2-hydroxybenzoic acid, styrene and oxozinc
- Test material form:
- liquid - solid: mixture of
- Remarks:
- water and Reaction products of 2-hydroxybenzoic acid and styrene and zinc oxide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality observed
- Clinical signs:
- other: no clinical sign observed
- Body weight:
- other body weight observations
- Remarks:
- Body weight increased
- Gross pathology:
- No pathological changes were observed at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Oral LD50 was greater than 5000 mg/kg bw for both mele and female Wistar rats.
- Executive summary:
In the acute oral toxicity study according to OECD TG 401, 10/sex/group of rats were administrated with test item (5000 mg/kg/bw) by oral gavage. No toxic signs were observed after application of test item, and no death occurred within two weeks.No pathological changes were observed at necropsy.Oral LD50 was greater than 5000 mg/kg bw for both male and female Wistar rats.
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