Registration Dossier
Registration Dossier
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EC number: 401-100-0 | CAS number: 109037-78-7 TILCOM CA35; TILCOM IA10; TYTAN AP 100; TYTAN CA 100; TYTAN CX 35; TYZOR IAM
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Information from migrated NONS file, as per inquiry number 06-2120053135-66-0000, permission to refer granted by ECHA
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 2 014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V
- GLP compliance:
- yes
Test material
- Reference substance name:
- Butyl (dialkyloxy(dibutoxyphosphoryloxy))titanium(trialkyloxy)titanium phosphate
- EC Number:
- 401-100-0
- EC Name:
- Butyl (dialkyloxy(dibutoxyphosphoryloxy))titanium(trialkyloxy)titanium phosphate
- Cas Number:
- 109037-78-7
- Molecular formula:
- not applicable
- IUPAC Name:
- dititanium(4+) triethanolate bis(propan-1-olate) dibutyl phosphate butyl phosphate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Amount / concentration applied:
- MG
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- 24/48/72 h
- Score:
- 2
- Reversibility:
- other: summary provided by ECHA 2014
- Remarks on result:
- other: summary provided by ECHA 2014
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- 24/48/72 h
- Score:
- 2
- Reversibility:
- other: summary provided by ECHA 2014
- Remarks on result:
- other: summary provided by ECHA 2014
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- 24/48/72 h
- Score:
- 2
- Reversibility:
- other: summary provided by ECHA 2014
- Remarks on result:
- other: summary provided by ECHA 2014
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- 24/48/72 h
- Score:
- 2
- Reversibility:
- other: summary provided by ECHA 2014
- Remarks on result:
- other: summary provided by ECHA 2014
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- 24/48/72 h
- Score:
- 2
- Reversibility:
- other: summary provided by ECHA 2014
- Remarks on result:
- other: summary provided by ECHA 2014
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- 24/48/72 h
- Score:
- 2
- Reversibility:
- other: summary provided by ECHA 2014
- Remarks on result:
- other: summary provided by ECHA 2014
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- 24/48/72 h
- Score:
- 2
- Reversibility:
- other: summary provided by ECHA 2014
- Remarks on result:
- other: summary provided by ECHA 2014
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Remarks:
- (mean scire 2)
- Time point:
- 24/48/72 h
- Score:
- 1
- Reversibility:
- other: summary provided by ECHA 2014
- Remarks on result:
- other: summary provided by ECHA 2014
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- 24/48/72 h
- Score:
- 1
- Reversibility:
- other: summary provided by ECHA 2014
- Remarks on result:
- other: summary provided by ECHA 2014
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- 24/48/72 h
- Score:
- 1
- Reversibility:
- other: summary provided by ECHA 2014
- Remarks on result:
- other: summary provided by ECHA 2014
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- 24/48/72 h
- Score:
- 1
- Reversibility:
- other: summary provided by ECHA 2014
- Remarks on result:
- other: summary provided by ECHA 2014
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- 24/48/72 h
- Score:
- 1
- Reversibility:
- other: summary provided by ECHA 2014
- Remarks on result:
- other: summary provided by ECHA 2014
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
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