Butyl (dialkyloxy(dibutoxyphosphoryloxy))titanium(trialkyloxy)titanium phosphate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data from secondary source

Data source

Reference

Reference 1

Reference Type:

other: Authoritive database

Title:

Acute inhalation toxicity for CAS no: 126-71-6

Author:

IFA GESTIS

Year:

2017

Bibliographic source:

GESTIS SUBSTANCE Database (information system in hazardous substance of the Berufsgenossenscheftn).

Reference 2

Reference Type:

review article or handbook

Title:

Toxicological evaluation no.122 triisobutyl phosphate

Author:

BG Chemie

Year:

2000

Bibliographic source:

BG Chemie,Toxicological evaluation no.122 triisobutyl phosphate 11/2000

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

Acute inhalation toxicity test was carried out to study the effects of Triisobutyl phosphate on rats

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Triisobutyl phosphate

EC Number:

204-798-3

EC Name:

Triisobutyl phosphate

Cas Number:

126-71-6

Molecular formula:

C12H27O4P

IUPAC Name:

Triisobutyl phosphate

Specific details on test material used for the study:

- Name of test material (as cited in study report):Triisobutyl phosphate
- Molecular formula :C12H27O4P
- Molecular weight :266.315g/mol
- Substance type:organic
- Physical state:No data available
- Purity:No data available
- Impurities (identity and concentrations):No data available

Test animals

Species:

rat

Strain:

other: Wistar(Hoe:WISKf/SPF71)

Sex:

male/female

Details on test animals or test system and environmental conditions:

Details on test animal
TEST ANIMALS
- Source: No data available
- Age at study initiation: No data available
- Weight at study initiation:205-188g
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): No data available - Water (e.g. ad libitum): No data available - Acclimation period: No data available

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available - Photoperiod (hrs dark / hrs light): No data available

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

nose/head only

Vehicle:

air

Mass median aerodynamic diameter (MMAD):

103 µm

Geometric standard deviation (GSD):

1.6

Details on inhalation exposure:

No data available

Analytical verification of test atmosphere concentrations:

yes

Duration of exposure:

4 h

Concentrations:

5.14 mg/L

No. of animals per sex per dose:

5 male and 5 female

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 21 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology were observed

Statistics:

No data available

Results and discussion

Preliminary study:

No data available

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 5.14 mg/L air

Based on:

test mat.

Exp. duration:

4 h

Remarks on result:

other: No mortality was observed

Mortality:

No deaths during study was observed.

Clinical signs:

other: Clinical signs included dyspnea, tremor, uncoordinated movements, a reduced level of spontaneous activity, ruffled fur, reduced startle reflexes and pinch reflexes, noses with bloody encrustations sneezing narrow palpebral fissure as well as reddish saliv

Body weight:

Body weight gain was impaired in the first week of post exposure observation. After 21 days the rats were free of symptoms again , with the exception of one female rats and their body weight had returned to normal

Gross pathology:

At necropsy at the end of the observation period approximately half of the animals exhibited discoloration of the lungs

Other findings:

No data available

Applicant's summary and conclusion

Interpretation of results:

other: Not classified

Conclusions:

LC50 value for acute inhalation toxicity test was considered to be >5.140mg/L .when rats were exposed with Triisobutyl phosphate (126-71-6) by inhalation for 4 hour.

Executive summary:

The acute inhalation toxicity study of Triisobutyl phosphate (126-71-6) was performed according to OECD guideline 403. 5 Male and 5 femaleWistar(Hoe:WISKf/SPF71) rats were exposed with test material in the concentration of 5.140mg/L inhaled (head/nose exposure ) for 4 hour. The median aerodynamic diameter being 1.3(with a geometric standard deviation of 1.6)All animals were observation for mortality and signs of toxicity for 21 days .No mortality were observed at dose concentration 5.140mg/L.Clinical signs included dyspnea, tremor, uncoordinated movements, a reduced level of spontaneous activity, ruffled fur, reduced startle reflexes and pinch reflexes, noses with bloody encrustations sneezing narrow palpebral fissure as well as reddish saliva and nasal discharge.

Body weight gain was impaired in the first week of post exposure observation. After 21 days the rats were free of symptoms again, with the exception of one female rats and their body weight had returned to normal. At necropsy at the end of the observation period approximately half of the animals exhibited discoloration of the lungs. HenceLC50value for acute inhalation toxicity testwas considered to be >5.140mg/L .when rats were exposed with Triisobutyl phosphate (126-71-6) by inhalation for 4 hour.