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EC number: 915-730-3
CAS number: -
In a local lymph node assay
according to OECD TG 429, groups of mice were topically treated on the
dorsal surface of both ears with 0 (vehicle), 2.5, 5.0, 10, 25 or 50%
(v/v) OTNE in 3:1 diethyl phthalate/ethanol daily for 3 days. On the 6thday,
mice were injected intravenously with H-thymidine and 5 hours later
were euthanized. The
draining auricular lymph nodes were extracted and prepared for
determination of H-thymidine content. All mice survived to
termination. Stimulation indices at 2.5, 5, 10, 25, and 50% were 1.4,
2.4, 5.2, 28.9, and 13.5, respectively. OTNE was considered to have skin
sensitising activity with an EC3 of 6.07%, indicating the concentration
at which a stimulation index of 3 is observed. A NOEC of 2.5% was
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