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EC number: 915-730-3
CAS number: -
In this in vitro assessment
of the mutagenic potential of OTNE, histidine dependent auxotrophic
mutants of S. typhimurium (strains
TA 1535, TA 1537, TA 1538, TA 98 and TA 100) and a tryptophan dependent
mutant of E. Coli (WP2uvrA)
were exposed to the test
substance, diluted in DMSO which was also used as a negative control. Two
independent mutation tests were performed, in the presence and absence
of liver preparations from Aroclor 1254-induced rats. In
the preliminary dose range finding study with dose levels of up to 5000
ug/plate, no toxicity was observed. A top dose level of 5000 ug/plate
was chosen for the subsequent mutation study. Other dose levels used in
the mutation assays were: 2500, 1250, 625, and 312.5 ug/plate. No
evidence of mutagenic activity was seen at any dose level of OTNE in
either mutation test. The
concurrent positive control compounds demonstrated the sensitivity of
the assay and the metabolising activity of the liver preparations. It
is concluded that OTNE tested in DMSO was not mutagenic in this
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