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Reaction product of {mixture of [poly(1~4)chlorosulfonylphthalocyaninato-N29,N30,N31,N32]copper(Ⅱ) and [poly(1~3) chlorosulfonyl (tribenzo[b,g,l]pyrido[2,3-q]-5,10,15,20-tetraazaporphyrinato-N21,N22,N23,N24)] copper(Ⅱ) and [poly(1~2) chlorosulfonyl (dibenzo[b,g(or b,l)]dipyrido [2,3(or 3,2)-l,q(or g,q)]-5,10,15,20-tetraazaporphyrinato-N21,N22,N23,N24)] copper(Ⅱ) and [monochlorosulfonyl (benzo[b]tripyrido [2,3(or 3,2)-g,l,q]-5,10,15,20-tetraazaporphyrinato-N21,N22,N23,N24)]copper(Ⅱ) }and 2-[4-(2-aminoethylamino)-6-(benzylamino)-1,3,5-triazin-2-ylamino]benzene-1,4-disulfonic acid, and ammonia water and sodium chloride
EC number: 700-815-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 February 2011 – 27 April 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study has been performed according to OECD and EC guidelines and in compliance with GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- (2004)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- (Official Journal of the European Union no. L142, May 31, 2008)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- E-C104
- IUPAC Name:
- E-C104
- Details on test material:
- - Name of test material (as cited in study report): E-C104
- Description: Blue powder
- Batch: MB-1
- Test substance storage: At room temperature protected from light
- Stability under storage conditions: Stable
- Expiry date: 23 December 2015
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- The concentration of the test substance in the test samples was determined immediately after preparation (t=0) and after 5 days. The samples taken at t=5 days were cooled to room temperature using running tap water. The samples were diluted by a factor of 2.5 with buffer pH 4, 7 or 9 and analysed.
- Buffers:
- - pH: 4
- Type and final molarity of buffer: Acetate buffer, 0.1 M
- Composition of buffer: solution of 16.6% 0.1 M sodium acetate and 83.4% 0.1 M acetic acid. The buffer contains 0.0009% (w/v) sodium azide.
- pH: 7
- Type and final molarity of buffer: Phosphate buffer, 0.1 M
- Composition of buffer: solution of 0.1 M potassium dihydrogenphosphate adjusted to pH 7 using 10 N sodium hydroxide. The buffer contains
0.0009% (w/v) sodium azide.
- pH: 9
- Type and final molarity of buffer: Borate buffer, 0.1 M
- Composition of buffer: solution of 0.1 M boric acid and 0.1 M potassium chloride adjusted to pH 9 using 10 N sodium hydroxide. The buffer
contains 0.0009% (w/v) sodium azide. - Details on test conditions:
- Preliminary test - Tier 1:
Test substance solutions were prepared in the buffer solutions at a target concentration of 1000 mg/l. Each solution was filter-sterilised through a 0.2 μm FP 30/0.2 CA-S filter (Whatman, Dassel, Germany) and transferred into a sterile vessel. To exclude oxygen, nitrogen gas was purged through the solution for 5 minutes. For each sampling time, duplicate sterile vessels under vacuum were filled with 6 ml test solution and placed in the dark in a temperature controlled environment at 49.9°C +/- 0.2°C.
Blank buffer solutions were treated similarly as the test samples and analysed at t=0.
The pH of each of the test solutions (except for the blanks) was determined at each sampling time.
Duration of test
- Duration:
- 5 d
- Initial conc. measured:
- > 952 - < 1 017 mg/L
- Number of replicates:
- 2 measurements at each pH (separate vessels)
Results and discussion
- Preliminary study:
- At pH 4, pH 7 and pH 9, a degree of hydrolysis of < 10% was observed after 5 days. It demonstrated that the half-life time of the test substance at 25°C is > 1 year. According to the guideline, no further tests were required.
No test substance was detected in blank buffer solutions. - Test performance:
- The mean recoveries of the buffer solutions fell within the criterion range of 90-110%. It demonstrated that the analytical method was adequate to support the hydrolysis study on the test substance.
- Transformation products:
- no
Total recovery of test substance (in %)open allclose all
- % Recovery:
- >= 97 - <= 98
- pH:
- 4
- Temp.:
- 49.9 °C
- Duration:
- 5 d
- % Recovery:
- >= 99 - <= 101
- pH:
- 7
- Temp.:
- 49.9 °C
- Duration:
- 5 d
- % Recovery:
- >= 98 - <= 99
- pH:
- 9
- Temp.:
- 49.9 °C
- Duration:
- 5 d
Dissipation DT50 of parent compound
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
Any other information on results incl. tables
Preliminary test – hydrolysis of the test substance at pH 4, pH 7 and pH 9 measured at 268 nm
pH code |
Sampling time |
Analysed concentration |
Degree of hydrolysis |
Actual pH |
|
Individual |
Mean |
||||
|
|
|
|
|
|
pH 4 |
0 hours |
955 |
|
|
4.0 |
|
|
967 |
|
|
4.0 |
|
5 days |
955 |
0.6 |
0.1 |
4.0 |
|
|
966 |
-0.5 |
|
4.0 |
|
|
|
|
|
|
pH 7 |
0 hours |
1013 |
|
|
7.1 |
|
|
1017 |
|
|
7.1 |
|
5 days |
1033 |
-1.8 |
-1.2 |
7.1 |
|
|
1021 |
-0.6 |
|
7.1 |
|
|
|
|
|
|
pH 9 |
0 hours |
1015 |
|
|
9.0 |
|
|
1012 |
|
|
9.0 |
|
5 days |
1027 |
-1.3 |
-1.1 |
9.0 |
|
|
1023 |
-0.9 |
|
9.0 |
|
|
|
|
|
|
Preliminary test – hydrolysis of the test substance at pH 4, pH 7 and pH 9 measured at 617 nm
pH code |
Sampling time |
Analysed concentration |
Degree of hydrolysis |
Actual pH |
|
Individual |
Mean |
||||
|
|
|
|
|
|
pH 4 |
0 hours |
952 |
|
|
4.0 |
|
|
970 |
|
|
4.0 |
|
5 days |
954 |
0.7 |
0.7 |
4.0 |
|
|
954 |
0.7 |
|
4.0 |
|
|
|
|
|
|
pH 7 |
0 hours |
1000 |
|
|
7.1 |
|
|
1011 |
|
|
7.1 |
|
5 days |
1014 |
-0.9 |
-0.6 |
7.1 |
|
|
1010 |
-0.4 |
|
7.1 |
|
|
|
|
|
|
pH 9 |
0 hours |
1010 |
|
|
9.0 |
|
|
1007 |
|
|
9.0 |
|
5 days |
1004 |
0.5 |
0.5 |
9.0 |
|
|
1003 |
0.6 |
|
9.0 |
|
|
|
|
|
|
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The preliminary test (Tier 1) was performed for the determination of the rate of hydrolysis of E-C104 at pH values normally found in the environment (pH 4-9).
At each pH value a degree of hydrolysis of < 10% was observed after 5 days. According to the guideline, performance of the main study (Tier 2) was not required. The half-life time of the test substance at 25°C was > 1 year at each pH tested.
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