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EC number: 700-815-8
CAS number: -
A single oral administration of E-C104 (dissolved in water) by gavage
was conducted to female 9 weeks old Crl:CD(SD) rats to evaluate its
acute oral toxicity in accordance with the OECD test guideline 423. A
dose of 2000 mg/kg was employed for the first and second administration
to each three rats. As a result, there was no mortality, body weight
gain effects, or necropsy findings. Clinical signs were restricted to
test substance mixed feces and chromaturia (bluish). In conclusion, the
LD50 of E-C104 in rats was estimated to be 2000 mg/kg or above under the
conditions of this study.
The acute inhalation toxicity of E-C104 was tested in Sprague-Dawley
rats. Animals were exposed for 4 hours in a snout-only exposure chamber
to 5 mg/L (5m, 5f) or 2 mg/L (5m). MMAD and GSD were 4.49 µm and
2.34, respectively (high dose), and 4.28 µm and 2.11, respectively (low
dose). In the low dose group, no mortality was observed, whereas 1 male
rat died in the high dose group the day after exposure. No
clinical signs were observed in the low dose group. In the high dose
group, sedation, deep respiration and labored respiration until one day
after exposure, which disappeared on day 2 after exposure. In the low
dose group, body weight losses were noted in all animals on day 1 after
exposure, in 3 males on day 3 after exposure and in 1 male on day 7
after exposure (as compared with body weight before exposure). In the
high dose group, body weight losses were noted in all animals on day 1
after exposure and in 4 males on day 3 after exposure (as compared with
body weight before exposure). All animals gained their body weights at
the end of the observation period (14 days after exposure). No
macroscopic abnormalities were noted in any surviving animal at the end
of the observation period. Based on these results, The LC50 of E-C104
for both sexes of Sprague-Dawley rats in this study is therefor more
than 5 mg/L.
E-C104 was administered once percutaneously to five male and five female
Crl:CD(SD) rats at a dose of 2000 mg/kg to evaluate its acute dermal
toxicity in accordance with OECD test guideline 402. The dose was
appllied for 24 hours occlusively after which the application site was
wiped. As a result, no mortality occurred in either sex and no test
substance related change was seen in clinical signs, body weight or
necropsy. Therefore, the LD50 value of E-C104 in rats was considered to
be more than 2000 mg/kg under the conditions of this study.
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