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EC number: 700-815-8
CAS number: -
The acute eye irritation or corrosion potential of E-C104 was assessed
in six (3 eye unwashed and 3 eye washed animals) male New Zealand White
rabbits. The test substance (0.1 g) was instilled into the right eye of
the animal. As a result, conjunctival redness and discharge of score 1
and chemosis of score 2 was observed in all animals of eye unwashed
animals at 1 hour after administration. These changes were fully
reversible within 24 hours. In the eye washed animals conjuncitval
redness and discharge of score 1 and chemosis of score 2 were observed
in two animals, and conjunctival redness, chemosis and discharge of
score 1 were observed in one animal at 1 hour after administration.
These effects were also fully reversible within 24 hours. The MMTS of
the eye unwashed and washed animals was 8 and 7.3, respectively, showing
no effect of the eye washing. Pigmentation of the conjunctivae was noted
in all animals. In conclusion, E-C104 had minimal eye irritation
potential to the rabbit eye under the conditions of this study.
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