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EC number: 252-044-7
CAS number: 34455-00-0
The skin irritation potential of the test article was evaluated in
albino rabbits. The test was conducted under OECD GLP (1997) conditions.
The test method was based on OECD No. 404 (2002), EC No. 440 (2008), US
EPA, OPPTS 870.2500 (1998), and JMAFF Guidelines (2011). Three male
rabbits were exposed to 0.5 grams of the test article moistened with
water by application onto clipped skin for 4 hours using a
semi-occlusive dressing. Sites were cleaned of residual test substance
using tap water after 4 hours of exposure. Animals were observed twice
daily for mortality/viability, at least once daily for toxicity, and
body weight was taken on the day of treatment (prior to application) and
after the final observation. The exposed sites were examined at 1, 24,
48, and 72 hours and scored for erythema and edema. Erythema and edema
scores of zero were reported at all time points for all animals
(PII=0.0/8.0). Based on the results of the study (all scores 0,
PII=0.0/8.0), the test article is not a skin irritant.
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