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EC number: 252-044-7
CAS number: 34455-00-0
The dermal lethality potential of the test article was evaluated
in male and female Sprague Dawley rats. The study was performed in
compliance with OECD GLP regulations. The test was performed according
to OECD 402. Rats (5 males and 5 females) received a 24-hour dermal
exposure of 2000 mg/kg. The test article was moistened with distilled
water on porous gauze and applied to the dorsal region (clipped, 10%
body surface) of each rat. The exposure site was wrapped with porous
dressing and porous non-irritating tape (semi-occlusive). After 24 hours
the gauze was removed and any remaining test article was removed by
washing with distilled water. All rats survived the study. Clinical
observations included chromorhinorrhea and wetness of the anogenital
area. Immediately following unwrapping, erythema was absent to very
slight and edema was absent. By Day 14, erythema and edema were
absent. Based on the results of the study, the rat dermal LD50 of the
test article is greater than 2,000 mg/kg body weight.
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