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EC number: 252-044-7
CAS number: 34455-00-0
The acute oral toxicity potential of the test article was
evaluated in Wistar rats. The study was performed in compliance with
OECD GLP (1997). The test method was based OECD 423 (2001). The test
material was dissolved in propylene glycol to achieve the appropriate
dose. Fasted female rats (n = 3) received a single 2000 mg/kg oral dose
of the test article via gavage at a volume of 10 mL/kg. As all animals
survived that dosing, another group of 3 female rats were dosed in a
similar manner. Observations for mortality were made twice daily and
body weights were collected on Days 1, 8, and 15. Observations for
clinical signs of toxicity were made daily. Necropsy was performed on
all animals at termination. All animals survived for the duration of the
study. Hunched/flat posture (3 animals, and piloerection (4 animals) was
observed through Day 2. Uncoordinated movements, lethargy and slow
breathing were noted in all animals on the day of exposure at up to 4
hours postdose. The body weight gains were considered normal. No gross
abnormalities were observed at necropsy.
Based on the results of the test, the oral LD50 of the test article is
greater than 2000 mg/kg bw in rats.
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