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EC number: 252-044-7
CAS number: 34455-00-0
for FBSEE diol
measured to be 2.7 (0.65% RSD) at an average temperature of 22°C
n-Octanol/Water Partition Coefficient (log Kow) of FBSEE diol was
determined according to U.S EPA guidance
document OPPTS 830.7550 "Partition Coefficient (n-Octanol/Water), Shake
Flask Method" and was conducted under GLP. Duplicate samples of FBSEE
diol were prepared in each of the three octanol/water ratios (1:1, 2:1,
and 1:2) at an average temperature of 22 °C. The samples were rotated
180 ° about their transverse axis for more than 50 rotations over a
nominal 24 hour period at > 28 RPM to ensure proper mixing of the test
system solvents. The samples were then centrifuged at 1500 RPM for 20
minutes, and the aqueous and n-octanol phases were carefully removed.
For each test vial, duplicate aliquot of water and n-octanol phase were
diluted and analyzed using LC/MS/MS. The determined log Kow values
ranged from 2.64 to 2.68 for all six samples. The overall average log
Kow was 2.7, and overall RSD% was 0.65%. This is a guideline study
conducted under GLP compliance. Therefore,
it is considered reliable without restrictions (Klimisch 1) anda
previous experiment was conducted accordingto
the OECD 117 (Partition Coefficient (n-octanol / water), HPLC Method)
but was not conducted under GLP. A single solution containing the FBSEE
diol and six calibration compounds was prepared at 0.1 to 0.3% level in
acetonitrile, and analyzed in duplicates by HPLC with Refractive Index
(RI) detector. The log Kow of FBSEE diol was determined to be 2.68. This
is a guideline study, however, it lacks analytical details and was not
conducted under GLP. Therefore, it is considered reliable with
restrictions (Klimisch 2) and a supporting study.
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