Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1955
Report Date:
1955

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Not specified
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
not specified
Dose descriptor:
LD100
Effect level:
1 000 mg/kg bw
Based on:
test mat.
Sex:
not specified
Dose descriptor:
LD0
Effect level:
500 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

Material Condition of skin No. of Application Site Response - Remarks
100% Intact 1 Ear Slight reddening of the skin, a trace of edema, and slight necrosis developing to scab and scar formation.
100% Intact 1 Belly Moderate reddening of the skin, trace of edema, moderate necrosis developing to scab and scar formation.
100% Abraded 1 Belly Moderate reddening of the skin, trace of edema, moderate necrosis developing to heavy scab and scar formation.
10 % in Dowanol 50 B Intact 10 Ear No response developing to a slight reddening of the skin and slight necrosis after 6 or 7 applications.
11 % in Dowanol 50 B Intact 4 Belly Essentially no response developing to moderate reddening of the skin and slight necrosis after 4 applications.
12 % in Dowanol 50 B Abrades 3 Belly Essentially no response developing to marked edema and necrosis after 3 applications with development of heavy scab and scar formation 

Skin contact - Absorption (24 hours Exposure)

Animal Preparation used Dose (g/kg) No. died / No. Treated Response - Remarks
Rabbit 10 % in propylene glycol 0.5 0/2 No apparent effect other than extensive scab and scar formation
Rabbit 10 % in propylene glycol 1.0 2/2 Death occurred in 1 day

Applicant's summary and conclusion

Interpretation of results:
other: Category 3 based on EU GHS
Conclusions:
The undiluted test material vinylbenzyl chloride has a severe effect on intact and abraded skin. Repeated, prolonged contact, over a period of 1 to 2 days is capable of causing marked to severe damage.
This material is markedly irritating and damaging to skin on prolonged or repeated contact. It has a moderate acute toxicity by skin absorption.
Executive summary:

The undiluted test material vinylbenzyl chloride has a severe effect on intact and abraded skin. Repeated, prolonged contact, over a period of 1 to 2 days is capable of causing marked to severe damage.

This material was found to be markedly irritating and damaging to skin on prolonged or repeated contact. It had a moderate acute toxicity by skin absorption. After 24 hours skin contact / absorption at a dose of 0.5 g/kg bw (10% solution in propylene glycol), no death and no apparent effect other than extensive scab and scar formation was noted in 2 out of 2 exposed animals. At a dose level of 1 g/kg bw 2 test animals died within 1 day. Based on these these observations, vinylbenzyl chloride was classified in Cat. 3 of acute dermal toxicity.