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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1955
Report Date:
1955

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Two rats per dose level were orally treated with different doses of the test substance vinylbenzyl chloride in corn oil.
GLP compliance:
no
Test type:
other: not specified, probably similar to standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
corn oil
Remarks:
10 %
Doses:
0.126, 0.252, 0.5, 1.0 g/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Statistics:
not reported

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 500 - < 1 000 mg/kg bw
Based on:
test mat.
Mortality:
Mortality occurred in 1 day after exposure to 1000 mg/kg bw (2 of 2 rats).

Any other information on results incl. tables

Animal Preparation Fed Dose (g/kg) No died / No fed Response-Remarks
Rat 10 % in corn oil 0.126 0/2 Slight irritation of the stomage. No other symptoms noted.
0.252 0/2 Moderate irritation of the stomach and slight kidney pathology noted.
0.5 0/2 Slight initial weight loss.
1.0 2/2 Death occured in 1 day.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
This material vinylbenzyl chloride has a moderate acute oral toxicity. After oral uptake of 1 g of test substance per kg body weight (10 % in corn oil) death of the treated rat occured in one day.
Executive summary:

Two rats were treated with different doses of the test substance vinylbenzyl chloride in corn oil. At a concentration of 1 g/kg all test animals died after 1 day. At a dose of 0.5 g/kg only slight initial weight loss occured, at 0.252 g/kg moderate irritation of the stomach and slight kidney pathology was noted and at a dose of 0.126 g/kg slight irritation of the stomach and no other symptoms were noted.