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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Title:
Unnamed
Year:
1970
Report Date:
1970

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Groups of five rats, weighing 300 to 400 grams each, were exposed for 205 to 455 min to the vapors under dynamic conditions in a glass exposure jar.
During the exposures, the animals were observed for signs of irritation and respiratory distress. After the exposures, necropsies were done on the animals which succumbed. The survivors were kept for various observations for a 14-day period. Thereafter, the animals were sacrificed for gross pathological examinations.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
weighing 300 - 400 grams each

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LC0
Effect level:
3.66 mg/L air (nominal)
Based on:
test mat.
Exp. duration:
405 min
Remarks on result:
other: vapour generation temperature: 23-25°C
Key result
Sex:
not specified
Dose descriptor:
LC100
Effect level:
3.74 mg/L air (nominal)
Based on:
test mat.
Exp. duration:
420 min
Remarks on result:
other: vapour generation temperature: 60C, cooled to room temperature prior to exposure

Any other information on results incl. tables

Gross necropsy
Compound Vapor generation
temperature
Nominal
Concentration
Expo.
Dur.
Observations Mortality Survivors
During Exposure Post Exposure During Expo. Post Expo. Deaths 1 Day 14 Days
°C mg/L ppm min.
Vinylbenzyl chloride
B.P. = 228 °C
1 mg/L = 160.2 ppm
23-25 3.66 ≈ 586 405 - Slight eyes and  nose irritation
- slight labored breathing
- lethargic
- Body weight loss for 4-5 days
- One rat acquired lung rattle for approx. 1.5 weeks
- Appreared normal at end of 2 weeks
0/5 0/5 -- no visible
lesion
no visible
lesion
60 3.74 ≈ 600 420 - slight eyes and nose irritation
- slight labored breathing
- lethargic
- Body weight loss
- severe respiratory rales
- fur stained yellow
0/5 5/5
(in 5 days)
- corneal damage
- pulmonary congestion and hemorrhage
no visible
lesion
--
140 31.55 ≈ 5050 255 - Eyes and nose irritation
- Dyspnea
- Prostration
- Death
5/5 -- - Pulmonary edema -- --

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
At a nominal concentration of 3.66 mg/L for 405 minutes of vinylbenzyl chloride no mortality occurred and no visible lesion. At 3.74 mg/L for 420 minutes all test animals died in 5 days after exposure and at a concentration of 31.55 mg/L and 255 minutes the animals died during exposure. The observed acute inhalative toxicity corresponds to Category 3. Eye and nose irritation is observed at every concentration.
Executive summary:

At a nominal concentration of 3.66 mg/L for 405 minutes of vinylbenzyl chloride no mortality occurred and no visible lesion. At 3.74 mg/L or 420 minutes all test animals died in 5 days after exposure and at a concentration of 31.55 mg/L and 255 minutes the animals died during exposure. The observed acute inhalative toxicity corresponds to Category 3. Eye and nose irritation is observed at every concentration.