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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from IUCLID dataset

Data source

Reference
Reference Type:
secondary source
Title:
Acute oral toxicity of CAS no 105-59-9
Author:
European Chemicals Bureau
Year:
2000
Bibliographic source:
IUCID Data set, European Chemicals Bureau, 18–FEB–2000, 58

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity study of Ethanol, 2.2’-(methylimino)bis- in rats
GLP compliance:
not specified
Test type:
other: Range finding test - Single dose oral toxicity
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
other: Liquid
Details on test material:
- Name of test material (as cited in study report): Ethanol, 2.2’-(methylimino)bis- (MDEA)
- Molecular formula (if other than submission substance): C6H13NO
- Molecular weight (if other than submission substance): 115.175 g/mole
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
other: Carworth–Wistar
Sex:
not specified
Details on test animals and environmental conditions:
- Fasting period before study: No, animals were not fasted before dosing.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
No data available
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
Duration of observation period following administration: 14 days
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 780 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality observed
Mortality:
50 % mortality observed in treated rats
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
LD50 was determined to be 4780 mg/kg bw when Carworth–Wistar rats were treated with Ethanol, 2.2’-(methylimino)bis- (MDEA) orally by gavage.
Executive summary:

In oral toxicity study,five Carworth–Wistar rats were treated with Ethanol, 2.2’-(methylimino)bis- (MDEA) in the concentration in a logarithmic series. 50 % mortality observed in treated rats at 4780 mg/kg bw. Therefore, LD50 was considered to be 4780 mg/kg bw when Carworth–Wistar rats were treated with Ethanol, 2.2’-(methylimino)bis- (MDEA) orally by gavage. This value indicates that the chemical is non toxic to rat and does not classify under Acute oral toxic category as per CLP regulation.