## Registration Dossier

Physical & Chemical properties

## Density

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### Link to relevant study record(s)

##### Reference
Endpoint:
density
Remarks:
density
Type of information:
experimental study
key study
Study period:
25-04-2017 – 25-04-2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental result performed using standard methods of analysis
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Principles of method if other than guideline:
Determination of the mass at a given temperature of a volume of the material contained in a density bottle (pycnometer) and determination of the volume of the latter by determining the mass of the corresponding volume of water at the same temperature. The density is obtained by dividing the mass of material by its volume.
GLP compliance:
no
Type of method:
other: IS 4730 : 1994 (Reaffirmed 2010) – Method for Determination of Density of Liquids (First Revision)
Test material information:
Composition 1
Specific details on test material used for the study:
- Name of test material (as cited in study report): 1-methylpiperidin-4-ol
- Molecular formula: C6H13NO
- Molecular weight: 115.175 g/mol
- Substance type: Organic
- Physical state: Liquid
Key result
Type:
density
Density:
0.978 g/cm³
Temp.:
20 °C
Remarks on result:
other: At. press: 971.7 hPa.

Calculations:

For Liquids
Density =(M1+A)x ρtw
(M2+A)

 1st calculated density 2nd calculated density 49.3851 x 0.9982 = 0.9887 g/cm³49.8581 48.5725 x 0.9982 = 0.9663 g/cm³50.1755 Average density = 0.9775 g/cm³
Conclusions:
The mean density of 1-methylpiperidin-4-ol (CAS No. 106-52-5) was determined to be 0.9775 g/cm³ at 20°C and 971.7 hPa.
Executive summary:

The density of test item 1-methylpiperidin-4-ol (CAS No. 106-52-5)was determined following OECD Guideline 109 and according to the IS 4730 : 1994 (Reaffirmed 2010) – Method for Determination of Density of Liquids (First Revision) using glass pycnometer.The mean density of test item was determined to be 0.9775 g/cm³ at 20°C and 971.7 hPa.

### Description of key information

The mean density of 1-methylpiperidin-4-ol (CAS No. 106-52-5) was determined to be 0.9775 g/cm³ at 20°C and 971.7 hPa.

### Key value for chemical safety assessment

Relative density at 20C:
0.978

The density of test item 1-methylpiperidin-4-ol (CAS No. 106-52-5)was determined following OECD Guideline 109 and according to the IS 4730 : 1994 (Reaffirmed 2010) – Method for Determination of Density of Liquids (First Revision) using glass pycnometer. The mean density of test item was determined to be 0.9775 g/cm³ at 20°C and 971.7 hPa.

Other supporting data from chemspider, 2012 and safety data sheet by sigma aldrich 2014, also indicates the density of chemical 1-methylpiperidin-4-ol to be 0.98 g/cm3