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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from OECD SIDS document.

Data source

Reference
Reference Type:
secondary source
Title:
Acute dermal toxicity of CAS no 105-59-9
Author:
US/ICCA
Year:
2012
Bibliographic source:
SIDS initial assessment profile, CoCAM2, 17-19 April 2012

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Version / remarks:
as below
Principles of method if other than guideline:
Acute dermal toxicity study of Ethanol, 2.2’-(methylimino)bis- in rabbits
GLP compliance:
not specified
Test type:
other: No data
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
other: Liquid
Details on test material:
- Name of test material (as cited in study report): Ethanol, 2.2’-(methylimino)bis- (MDEA)
- Molecular formula (if other than submission substance): C6H13NO
- Molecular weight (if other than submission substance): 115.175 g/mole
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
No data
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
- Other examinations performed: clinical signs were observed.
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No effect on survival and clinical sign
Mortality:
No mortality observed in treated rabbits
Clinical signs:
Sluggishness, unsteady gait, emaciation and prostration were observed after application of undiluted MDEA in treated rabbits but, surviving animals recovered during the observation period.
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
LD50 was considered to be > 2000 mg/kg bw when rabbits were treated with Ethanol, 2.2’-(methylimino)bis- (MDEA) dermally.
Executive summary:

In dermal toxicity study,rabbits were treated with Ethanol, 2.2’-(methylimino)bis- (MDEA) in the concentration of 2000 mg/kg bw dermally. No mortality observed in treated rabbits. Sluggishness, unsteady gait, emaciation and prostration were observed after application of undiluted MDEA in treated rabbits but, surviving animals recovered during the observation period. Therefore, LD50 was considered to be > 2000 mg/kg bw when rabbits were treated with Ethanol, 2.2’-(methylimino)bis- (MDEA) dermally.