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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
26-04-2017 – 29-04-2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental result performed using standard methods of analysis
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Type of method:
other: spectrophotometric method
Test material information:
Composition 1
Specific details on test material used for the study:
- Name of test material (as cited in study report): 1-methylpiperidin-4-ol
- Molecular formula: C6H13NO
- Molecular weight: 115.175 g/mol
- Substance type: Organic
- Physical state: Liquid
Key result
Water solubility:
105 579.95 mg/L
Conc. based on:
test mat.
Temp.:
30 °C
Remarks on result:
other: other details not available

Table 2:

Sample stirring

Concentration obtained on

the basis of standard curve

Dilution factor

Solubility value obtained

(mg/L)

24 hour

-

-

-

48 hour

297.4015 mg/L

400

118960.6 mg/L

72 hour

307.3310 mg/L

300

92199.3 mg/L

Considering the water solubility for 48 hrs and 72 hrs the mean water solubility was calculated as follows:

Mean water solubility value for 48 hour run sample + 72 hour run sample

= (118960.6+92199.3)/2

= 105579.95 mg/L

Conclusions:
The water solubility for the test item 1-methylpiperidin-4-ol was determined to be 105579.95 mg/L at 30°C.
Executive summary:

The water solubility determination of test item 1-methylpiperidin-4-ol (CAS No. 106-52-5) was done as per the OECD guideline 105 by spectrophotometric analytical method. The solubility of (1-methylpiperidin-4-ol of 106-52-5) in water was determined to be 105579.95 mg/L at 30°C. Based on this value, 1-methylpiperidin-4-ol can be considered to be highly soluble in water.

Description of key information

The water solubility for the test item 1-methylpiperidin-4-ol was determined to be 105579.95 mg/L at 30°C.

Key value for chemical safety assessment

Water solubility:
105 579.95 mg/L
at the temperature of:
30 °C

Additional information

The water solubility determination of test item 1-methylpiperidin-4-ol (CAS No. 106-52-5) was done as per the OECD guideline 105 by spectrophotometric analytical method. The solubility of (1-methylpiperidin-4-ol of 106-52-5) in water was determined to be 105579.95 mg/L at 30°C.

Other supporting datafrom various estimation models also suggests the estimated water solubility of 1 -methyl-4 -piperidinol was 1000000 mg/l at 25 deg C . Based on these values, 1-methylpiperidin-4-ol can be considered to be highly soluble in water.