Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Hydrolysis:
The estimated half-life of 1-methylpiperidin-4-ol was estimated to be 74.90 days, indicating that it is very negligibly hydrolysable.

Additional information

Hydrolysis:
Predicted data for test compound4-Piperidinol, 1-methyl-(CAS No. 106-52-5) and its read across substance for the hydrolysis end point which is summarized as below:

The Hydrolysis of 1-methylpiperidin-4-ol was predicted using OECD QSAR toolbox version 3.3 (2017). The estimated half-life of 1-methylpiperidin-4-ol was estimated to be 74.90 days.

In supporting study for RA, Hydrolysis of substance Aziridine was studied at neutral pH (7). The half-life of Aziridine was determined to be 154 days.

Base on the above values indicates that the test substance 1-methylpiperidin-4-ol is very negligibly hydrolysable.