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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
Data is from computational model developed by USEPA
Reference:
Composition 0
Qualifier:
according to
Guideline:
other: Modeling database
Principles of method if other than guideline:
Data is predicted by ECOSAR v1.1
GLP compliance:
no
Test material information:
Composition 1
Specific details on test material used for the study:
- Name of test material (as cited in study report): 1-methylpiperidin-4-ol
- Molecular formula: C6H13NO
- Molecular weight: 115.175 g/mol
- Substance type: Organic
- Physical state: Liquid
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Daphnia magna
Test type:
static
Water media type:
freshwater
Total exposure duration:
48 h
Hardness:
No data
Test temperature:
No data
pH:
No data
Dissolved oxygen:
No data
Salinity:
No data
Conductivity:
No data
Nominal and measured concentrations:
No data
Details on test conditions:
No data
Reference substance (positive control):
not specified
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
3 674.98 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
mobility
Validity criteria fulfilled:
not specified
Conclusions:
The predicted data by ECOSAR version 1.1, suggests the 48 hr lethal concentration (LC50) for the 4-Piperidinol, 1-methyl- (CAS no106-52-5) to be 3674.980mg/l for Daphnia magna.
Executive summary:

48 hrs aquatic toxicity studies (EPI suite, ECOSAR version 1.1, 2016) were conducted to assess toxic effects of the 4-Piperidinol, 1-methyl- (CAS no106-52-5) and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for the 4-Piperidinol, 1-methyl- (CAS no106-52-5) was estimated to be 3674.980mg/l

Based on the result the 4-Piperidinol, 1-methyl- was considered as not classified to aquatic invertebrates.

Description of key information

The predicted data by ECOSAR version 1.1, suggests the 48 hr lethal concentration (LC50) for the 4-Piperidinol, 1-methyl- (CAS no106-52-5) to be 3674.980mg/l for Daphnia magna.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
3 674.98 mg/L

Additional information

Various predicted studies and read across study for the 4-Piperidinol, 1-methyl-were reviewed to summarize the following information: 

48 hrs aquatic toxicity studies (EPI suite, ECOSAR version 1.1, 2016) were conducted to assess toxic effects of the 4-Piperidinol, 1-methyl- (CAS no106-52-5) and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for the 4-Piperidinol, 1-methyl- (CAS no106-52-5) was estimated to be 3674.980mg/l.

Using similar experimental conditions, 48 hr aquatic toxicity study (SSS QSAR prediction model, 2016) were conducted to assess toxic effects of the4-Piperidinol, 1-methyl- (CAS no106-52-5) and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the4-Piperidinol, 1-methyl- (CAS no106-52-5) was estimated to be 120 mg/L on the basis of intoxication.

A study was performed for read across chemical N-Methyldiethanolamine (105-59-9) as short term toxicity test (IUCLID dataset, European commission – European chemicals bureau,18–FEB–2000) in Daphnia magna for 48 hrs using guideline 79/831/EWG. The EC0, EC 50 and EC100 value in 48 hrs for short term toxicity to aquatic invertebrates for N-Methyldiethanolamine (105 -59 -9) were determined to be 125 mg/l, 230 mg/l and 500 mg/l respectively. Based on the result the N-Methyldiethanolamine was considered as not classified as per CLP regulation.

Another study on same read across cas was performed in Daphnia magna (Sids initial assessment profile, CoCAM2, 17-19 April 2012) for 48 hrs using guideline 79/831/EWG. From the experiment the EC0, EC 50 and EC100 value for short term toxicity to aquatic invertebrates for N-Methyldiethanolamine (105 -59 -9) were determined to be 250 mg/l, 400 mg/l and >500 mg/l. On the basis of result the N-Methyldiethanolamine was considered as not classified.

Based on the results of predicted data for target chemical and read across studies, it can be considered that the 4-Piperidinol, 1-methyl- (CAS No 106-52-5) is not likely to be toxic to aquatic invertebrates at environmentally relevant concentrations and can be considered as not classified as per the criteria of CLP regulation