Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-494-0 | CAS number: 121-71-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer- reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Oral Toxicity to Deer Mice
- Author:
- Schafer et al..
- Year:
- 1 985
- Bibliographic source:
- Archives of Environmental Contamination and Toxicology
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Acute oral toxicity for 3-Acetylphenol in deer mice was observed.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3'-hydroxyacetophenone
- EC Number:
- 204-494-0
- EC Name:
- 3'-hydroxyacetophenone
- Cas Number:
- 121-71-1
- Molecular formula:
- C8H8O2
- IUPAC Name:
- 1-(3-hydroxyphenyl)ethan-1-one
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): 3'-hydroxyacetophenone
- Molecular formula (if other than submission substance): C8-H8-O2
- Molecular weight (if other than submission substance): 136.149
- Smiles notation (if other than submission substance): c1(cc(ccc1)O)C(C)=O
- InChl (if other than submission substance): 1S/C8H8O2/c1-6(9)7-3-2-4-8(10)5-7/h2-5,10H,1H3
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- other: (mice)Peromyscus maniculatus
- Strain:
- other: deer
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Wild-trapped deer mice
- Age at study initiation: No data available
- Weight at study initiation: 20 gm
- Fasting period before study: No data available
- Housing: 2-4 individually caged deer mice.
- Diet (e.g. ad libitum): An alternate less preferred food (laboratory rodent pellets available ad lib.
- Water (e.g. ad libitum): water was available ad lib.
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
No data available
IN-LIFE DATES: From: To: No data available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: water, corn oil, or 1.0% carbopol
- Details on oral exposure:
- DOSAGE PREPARATION (if unusual): geometrically spaced dosage level were used.
- Doses:
- No data available
- No. of animals per sex per dose:
- 2-4 animals.
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration- 3 days
- Statistics:
- Thompson (1948) and Thompson and Weil (1952).
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- 1 600 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Approximate mortality
- Mortality:
- Approximate 50 % mortality may observed in treated mice by range-finding modification.
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Conclusions:
- Therefore, LD0 was considered to be 1600 mg/kg bw when deer (Peromyscus maniculatus) mice treated with 3-Acetylphenol orally by gavage.
- Executive summary:
Ina a acute oral toxicity was evaluated in deer Peromyscus maniculatus) mice by using 3-Acetylphenol orally by gavage using water, corn oil, or 1.0% carbopol as carriers, followed by 3-days of observations for mortality. Approximate Lethal Dose was observed between 470-1600 mg/kg bw. ALD (Approximate Lethal Dose) represented a range-finding modification of the Deichman and LeBlanc (1943) and not the LD50 determination. Using this single animal per level method, each succeeding treatment was 50% higher than the preceding level and continued until mortality occurred and No 50 % mortality was observed in treated mice at 1600 mg/kg bw. Therefore, LD0 was considered to be 1600 mg/kg bw when deer (Peromyscus maniculatus) mice treated with 3-Acetylphenol orally by gavage.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
