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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from peer- reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Acute Oral Toxicity to Deer Mice
Author:
Schafer et al..
Year:
1985
Bibliographic source:
Archives of Environmental Contamination and Toxicology

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Acute oral toxicity for 3-Acetylphenol in deer mice was observed.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material (as cited in study report): 3'-hydroxyacetophenone
- Molecular formula (if other than submission substance): C8-H8-O2
- Molecular weight (if other than submission substance): 136.149
- Smiles notation (if other than submission substance): c1(cc(ccc1)O)C(C)=O
- InChl (if other than submission substance): 1S/C8H8O2/c1-6(9)7-3-2-4-8(10)5-7/h2-5,10H,1H3
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
other: (mice)Peromyscus maniculatus
Strain:
other: deer
Sex:
not specified
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: Wild-trapped deer mice
- Age at study initiation: No data available
- Weight at study initiation: 20 gm
- Fasting period before study: No data available
- Housing: 2-4 individually caged deer mice.
- Diet (e.g. ad libitum): An alternate less preferred food (laboratory rodent pellets available ad lib.
- Water (e.g. ad libitum): water was available ad lib.
- Acclimation period: No data available


ENVIRONMENTAL CONDITIONS
No data available

IN-LIFE DATES: From: To: No data available

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: water, corn oil, or 1.0% carbopol
Details on oral exposure:
DOSAGE PREPARATION (if unusual): geometrically spaced dosage level were used.
Doses:
No data available
No. of animals per sex per dose:
2-4 animals.
Control animals:
not specified
Details on study design:
- Duration of observation period following administration- 3 days
Statistics:
Thompson (1948) and Thompson and Weil (1952).

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD0
Effect level:
1 600 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Approximate mortality
Mortality:
Approximate 50 % mortality may observed in treated mice by range-finding modification.
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
not classified
Conclusions:
Therefore, LD0 was considered to be 1600 mg/kg bw when deer (Peromyscus maniculatus) mice treated with 3-Acetylphenol orally by gavage.
Executive summary:

Ina a acute oral toxicity was evaluated in deer Peromyscus maniculatus) mice by using 3-Acetylphenol orally by gavage using water, corn oil, or 1.0% carbopol as carriers, followed by 3-days of observations for mortality. Approximate Lethal Dose was observed between 470-1600 mg/kg bw. ALD (Approximate Lethal Dose) represented a range-finding modification of the Deichman and LeBlanc (1943) and not the LD50 determination. Using this single animal per level method, each succeeding treatment was 50% higher than the preceding level and continued until mortality occurred and No 50 % mortality was observed in treated mice at 1600 mg/kg bw. Therefore, LD0 was considered to be 1600 mg/kg bw when deer (Peromyscus maniculatus) mice treated with 3-Acetylphenol orally by gavage.