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EC number: 251-649-3
CAS number: 33704-61-9
Please find in the table below the summary results.
Maximum score for:
Saline (negative control)
Not applicable, one eye tested
BAC 5% (w/v) (positive control)
The eye irritating potential of Cashmeran was determined in an isolated
chicken eye test performed according to OECD guideline 438 and under GLP
Cashmeran caused moderate swelling (20%) of the cornea, moderate or
moderate to severe corneal opacity (2.2) and moderate or moderate to
severe fluorescein retention (2.3). The negative control eye did not
show any corneal effect and demonstrated that the general conditions
during the tests were adequate. Furthermore, the positive control eyes
showed severe corneal effects and demonstrated the suitability and
sensitivity of the ICE to detect severe eye irritants. The irritation
index for Cashmeran as defined in the OECD guideline was 110 out of a
maximum of 240.
Based on the irritation index for Cashmeran the substance does not need
to be classified as severely irritating but according to the EU-CLP
classification schemes of the ICE, the substance should be classified as
irritating and Category 2: “Irritating to eyes”.
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