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EC number: 251-649-3
CAS number: 33704-61-9
Please find in the table below the summary results.
Maximum score for:
Saline (negative control)
Not applicable, one eye tested
BAC 5% (w/v) (positive control)
 Combinations of categories less likely to occur. The combination of 2 x III, and 1 x IV can be considered as a borderline case between irritating and severely irritating. These combinations can be considered as a borderline case between Category 2 and not irritating. Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006.
The eye irritating potential of Cashmeran was determined in an isolated chicken eye test performed according to OECD guideline 438 and under GLP conditions.
The test substance caused moderate swelling (20%) of the cornea, moderate or moderate to severe corneal opacity (2.2) and moderate or moderate to severe fluorescein retention (2.3). The negative control eye did not show any corneal effect and demonstrated that the general conditions during the tests were adequate. Furthermore, the positive control eyes showed severe corneal effects and demonstrated the suitability and sensitivity of the ICE to detect severe eye irritants. The irritation index for Cashmeran as defined in the OECD guideline was 110 out of a maximum of 240.
Based on the irritation index for Cashmeran the substance does not need to be classified as severely irritating but according to the EU-CLP classification schemes of the ICE, the substance should be classified as irritating and Category 2: “Irritating to eyes”.
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