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EC number: 251-649-3
CAS number: 33704-61-9
The ability of Cashmeran to induce
mutations was investigated in the Bacterial Reverse Mutation Assay
(Ames) by using 4 histidine-requiring strains of Salmonella typhimurium
(TA100, TA1535, TA98 and TA1537), and a tryptophan-requiring strain of
Escherichia coli (WP2 uvrA) with a pre-incubation method in the presence
and absence of a metabolic activation system (S9 mix). The study
procedures described in this reverse mutation assay were equivalent to
OECD guideline 471. Test concentrations used in the main test were as
follows: - S9 mix: 2.44, 4.88, 9.77, 19.5, 39.1 and 78.1 µg/plate; + S9
mix: 9.77, 19.5, 39.1, 78.1, 156, and 313 µg/plate.
The mutagenicity of the test compound
was judged negative because the number of revertant colonies in the test
compound treatment groups was less than twice that of each negative
control in all test strains. The number of revertant colonies in the
positive control groups were more than twice that of negative control
groups. The test results showed that the number of revertant colonies
for the negative control and the positive controls were within the range
of the historical data at Hita laboratory, indicating that the test can
be considered valid.
It is concluded that Cashmeran has no
ability to induce mutations in bacteria under the present test
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