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EC number: 271-089-3
CAS number: 68515-47-9
RS-Freetext:Absolute and relative LIVER WEIGHTS and relative KIDNEY WEIGHTS were INCREASED in animals given 1.2 or 2.5% DIDP. Both sexes given 2.5% DIDP showed INCREASES IN PEROXISOMENUMBERS AND SIZE, with the females showing a greaterresponse. INCREASES IN PALMITOYL CoA OXIDATION and TOTALHEPATIC PROTEIN LEVELS were also observed at these doses.
Di-isodecyl phthalate (the test substance) was fed to groups of five
male and five female F344 rats at dietary levels of 0, 0.3, 1.2, or 2.5%
for 21 days. A further group of five rats of each sex, fed 1.2% DEHP,
served as a study control. Male rats given 1.2 or 2.5% showed decreased
body weights as compared to control; this was seen in the females but to
a lesser extent. Food intakes were reduced initially in both sexes given
1.2 or 2.5%, the effect persisting throughout treament in males given
2.5%. Absolute and relative liver weights and relative kidney weights
were increased in both sexes given 1.2 or 2.5% test substance in the
feed. In males given 2.5%, relative testis weights were significantly
greater and no lesions were seen histologically. There was a reduction
in hepatocyte cytoplasmic basophilia in rats fed 1.2 or 2.5% and in the
latter group this was associated with an increase in eosinophilia. Lower
periportal lipid levels were seen but this was not dose related. Serum
tyiglycerides and cholesterol levels were reduced in males given 1.2 or
2.5% test substance, but no dose relationship was apparent. Both sexes
given 2.5% in feed showed a marked but variable increase in peroxisome
numbers and size, the females showing a greater response.
Cyanide-insensitive palmitoyl-CoA oxidation was significantly increased
in all treated animals except those given 0.3% in feed. There was a
significant increase in the 11- and 12- hydroxylation of lauric acid in
all treated males, but in the females the only significant increase was
in the 12- hydroxylase level in those given 2.5% of the test substance.
Therefore, the NOAEL = 0.3% (280 mg/kg/day) and LOAEL = 1.2% (1100
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