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EC number: 271-089-3
CAS number: 68515-47-9
acute and chronic aquatic toxicity studies with DTDP and with analogs of
DINP summarized in this report exhibit a range of maximum test substance
concentrations achieved under the specific conditions of the studies. In
those studies that did not use surfactants to increase aqueous
solubility of DTDP, differences in the reported measured water
solubilities are a result of several factors including different media
composition, test substance spiking methods influenced by partitioning
between test system and organism, different analytical techniques, and
improvements in analytical procedures that have produced greater
does not produce acute or chronic aquatic toxicity in fish,
invertebrates, and algae. Analogs of DTDP (DIDP and DUP) have also been
shown not to adversely impact the population parameters evaluated in a
multi-generation study with a fish species, demonstrating that DTDP does
not have the potential to cause endocrine disruption in the aquatic
environment. The absence of toxicity demonstrated by DTDP is, at least
in part, due to its low water solubility, resulting in low exposure
potential, as well as the ability of organisms to metabolize DTDP at a
rate that prevents a critical body burden from being reached. The data
for DTDP show that it is not toxic at its maximally attainable water
solubility level, which varies dependent on the conditions of study.
Since DTDP does not cause acute or chronic aquatic toxic effects at the
limits of water solubility, it is not possible to derive NOEC or PNEC
values needed for quantitative risk assessment. However, it is possible
to qualitatively conclude based on low solubility and the results of
acute and chronic aquatic toxicity tests that DTDP does not pose an
unacceptable risk to the aquatic compartment.
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