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EC number: 271-089-3
CAS number: 68515-47-9
In this study, rabbits were exposed to DTDP at doses of 50, 200, 794 and
3160 mg/kg body weight for 24 hours via occluded dermal contact and
evaluated in the methods of Draize. Dermal assessment occurred at 1, 2,
and 4 hours and once daily thereafter for 14 days post exposure
un-wrapping. Every animal survived the exposure. Dermal responses were
generally slight with the intensity and duration of the response
occurring in a dose-related pattern. Animals in the 50 and 200 mg/kg
dose groups generally exhibited barely perceptible erythema in response
to exposure. Most animals in the 794 mg/kg dose group exhibited very
slight or well-defined erythema at 24 hours, but were free of any dermal
irritation by day 3 post exposure un-wrapping. All animals in the 3160
mg/kg dose group exhibited erythema ranging in severity from very slight
to severe at 24 hours and on 3 days post exposure un-wrapping. All signs
of dermal irritation were absent by day 14. It is concluded that the
LD50 is greater than 3160 mg/kg.
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