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EC number: 271-089-3
CAS number: 68515-47-9
Male Sprague-Dawley rats were administered a single oral exposure of
DTDP (1.0, 1.47, 2.15, 3.16, 4.64, 6.81 and 10.0 g/kg) via oral gavage
after an 18 hour fasting period. Assessment for clinical signs of
toxicity occurred at 1, 2, and 4 hours after dosing and daily thereafter
for 14 days. All animals survived the exposure. There was no evidence of
a wasting syndrome as assessed by changes in bodyweight. Clinical signs
of urinary staining, fecal staining and stool softening were observed 2
hours post exposure in some dose groups, but these signs were not
present by 3 days post exposure. It is concluded that the LD50 is
greater than 10.0 g/kg.
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