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EC number: 203-838-7 | CAS number: 111-14-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Industrial Biotest Laboratory was found to use fraudulent practices in some of their studies and reports. Since these studies were performed before the implementation of Good Laboratory Practices, it is not possible to verify the scientific credibility of most of these studies.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Heptanoic acid
- EC Number:
- 203-838-7
- EC Name:
- Heptanoic acid
- Cas Number:
- 111-14-8
- Molecular formula:
- C7H14O2
- IUPAC Name:
- heptanoic acid
- Details on test material:
- substance: heptanoic acid (SN-1767)
physical state : a clear, colorless liquid.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:no data
- Age at study initiation:no data
- Weight at study initiation: no data
- Fasting period before study: yes, during the 16-hour period immediately prior to oral intubation
- Housing: in stock cages
- Diet (e.g. ad libitum): standard laboratory died, ad libitum
- Water (e.g. ad libitum): not precised, ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS : no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 1350, 4556, 6834, 10250 and 15380 mg/kg bw
- No. of animals per sex per dose:
- 2 animals/sexe/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: at the biginning and at 14 days.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 8 370 mg/kg bw
- Remarks on result:
- other: SD +/- 1203 mg/kg
- Mortality:
- 1350 mg/kg bw : no mortality
4556 mg/kg bw: no mortality
6834 mg/kg bw: 1 died animal (1F)
10250 mg/kg bw: 3 died (1M, 2F)
15380 mg/kg bw: 4/4 died - Clinical signs:
- other: Hypoactivity and salvation were observed at all doses. At 4556 mg/kg and above : labored breathing, muscular weakness, prostation. At 6834 mg/kg and above : vasoconstriction, diuresis At 10250 mg/kg and above : diarrhea
- Gross pathology:
- none
- Other findings:
- Necropsy examination of the animals that died revealed red and/or hemorrhaged lungs.
In addition, the rats at the 10250 and 15380 mg/kg dose levels exhibited chemical byrns in the gastrointestinal tracts and blood in the urinary bladders.
Applicant's summary and conclusion
- Conclusions:
- Heptanoic acid is pratically non toxic with a LD50 of 8370 mg/kg
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