Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-522-0 | CAS number: 61-90-5
Endpoint summary
Administrative data
Description of key information
Additional information
Although no tests are available that assess the aquatic toxicity of L-leucine to the relevant trophic levels, the aquatic toxicity of the substance can be sufficiently assessed based on the information available for the read-across substance L-valine. This read-across is deemed justified based on a comparison of the main factors driving environmental toxicity: pH, water solubility, log Kow and chemical reactivity (functional groups).
Based on this read-across, it can be concluded that acute toxicity to fish or aquatic invertebrates is not expected to occur upon exposure to up to 1000 mg/L of L-leucine.
Furthermore, QSAR information based on the EpiSuite (EcoSAR) model are added to the dossier to further substantiate the low toxicity of L-leucine to the aquatic compartment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
