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EC number: 208-796-3
CAS number: 542-02-9
An acute oral and an acute inhalation study with Acetoguanamine are available.The LD50 value (oral) for the test substance was calculated to be 2.74 g/kg body weight.Furthermore the LC50 value (inhalation) was calculated to be greater than 2.031 mg/L, which was considered to be the maximum practical with the atmosphere generation system used.
TABEL 1: The mortality in the test animals of the various dose groups
after the treatment with Acetoguanamine.
ml 20 % solution/kg
g test substance/kg
An acute oral toxicity test with Acetoguanamine was performed. No
guideline for the testing methode is mentioned in the report.
Nevertheless the test result seems to be reliable as the observation
period is also stated to be 14 days and the testing procedure as well as
the choice of doses seems to be reasonable.
On the basis of some preliminary observations the following doses were
given as as one single dose to groups of five male and five female rats:
2.0, 2.2, 2.4, 2.6, 2.8, 3.0 g test substance / kg bw.
The animals were observed for a 14 -day period. Then the survivors were
killed and examined grossly. With the obtained study results the LD50 of
Acetoguanamine was calculated to be 2.74 g/kg body weight. Because of
this reason Acetoguanamine is not classified as acute oral toxic.
The aim of this study was to determine the 4 -hour LC50 value
of Acetoguanamine. Each five male and female rats were exposed to the
test atmosphere generated by dispersing the powder continously in air by
means of a "Wright" dust feed mechanism with a mean measured
concentration in the atmosphere of 2.031 mg/L for four hours (head-only
The animals were observed for motality and signs of intoxication during
exposure and daily thereafter for 14 days. The particle size was
determined with 6 separation stages corresponding to maximum mass median
aerodynamic diameters of 0.52, 0.93, 1.55, 3.5, 6.0 and 9.8 µm.
Exposure of Acetoguanamine at a single chamber concentration of 2.031
mg/L did not cause mortality. Minor signs of toxicity such as changes in
clinical conditions and small body weight loss in treated females were
considered not to be significant signs of toxicity.
Using standard assessment crtiteria Acetoguanamine can be classified as
non-toxic or slightly toxic. As the maximum practical concetration used
produced only slight signs of toxicity Acetoguanamine should probably be
classified as non-toxic.
An acute oral and an acute inhalation study with Acetoguanamine are
The LD50 value (oral) for the test substance was calculated to be 2.74
g/kg body weight.
Furthermore the LC50 value (inhalation) was calculated to be greater
than 2.031 mg/L, which was considered to be the maximum practical with
the atmosphere generation system used. Also with this limit
concentration no deaths occurred.
According to Regulation (EC) No. 1272/2008 a LD50 oral value of more
than 2000 mg/kg body weight is not considered to indicate oral acute
toxicity. Furthermore the LC50 value (inhalation) was calculated to be
greater than 2.031 mg/L, which was considered to be the maximum
practical with the atmosphere generation system used. Also with this
limit concentration no deaths occurred.Therefore Acetoguanamine is also
not considered to indicate acute inhalation toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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