Registration Dossier

Administrative data

Description of key information

No data on repeated dose toxicity with Acetoguanamine are available. Because of animal welfare reasons a sub-chronic (90 days) study on Acetoguanamine should not be conducted before data on the prenatal developmental toxicity (OECD414) is available. Within this dossier a testing proposal is submitted (see Section 7.8.2 of the dossier).

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available (further information necessary)

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: inhalation - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

No data on repeated dose toxicity with Acetoguanamine are available. Because of animal welfare reasons a sub-chronic (90 days) study on Acetoguanamine should not be conducted before data on the prenatal developmental toxicity (OECD414) is available. Within this dossier a testing proposal is submitted (see Section 7.8.2 of the dossier).

Justification for classification or non-classification

No data on repeated dose toxicity with Acetoguanamine are available. Nevertheless there are no conclusive indications for a classification for repeated dose toxicity at this time. Evaluation will be considered based on the outcome of further sub-chronic repeated dose testing.