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EC number: 227-815-6
CAS number: 5989-54-8
Table 1: Individual and mean scores of
conjunctivae, iris and cornea
Time after treatment
Mean (24, 48 and 72 hours)
In an eye irritation study conducted
according to the OECD Guideline 405 and in compliance with GLP, three
male rabbits of the New Zealand White strain were exposed to 0.1 mL of
undiluted D-LIMONENE in one of the eyes while the other eye corresponded
to the control. The eyes were examined for irritation scores at 1 hour
and 1, 2, 3, 4 and 7 days after dosing.
Instillation of D-LIMONENE resulted in
slight to moderate redness of conjunctivae associated with moderate
chemosis in all treated animals after 1 hour of instillation. The
irritation completely resolved within 7 days. Mean individual scores at
24, 48 and 72 hours after exposure for the 3 animals were 0, 0, 0 for
cornea score; 0, 0, 0 for iris score; 0.3, 1, 1.3 for conjunctivae score
and 1, 0.3, 1 for chemosis score.
Under the test conditions, D-LIMONENE is not
classified as irritating to the eye according to the criteria of CLP
Regulation (EC) N° (1272-2008).
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