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EC number: 227-815-6
CAS number: 5989-54-8
Table 1: Skin irritation data for individual
Mean (24 hours + 48 hours + 72 hours)
* marked desquamation from skin surface
after 7 days
** desquamation from skin surface after 7
In a primary dermal irritation study performed according to OECD
guideline 404 and in compliance with GLP, three albino rabbits were
dermally exposed to 0.5 mL of undiluted d-limonene, under a
semi-occlusive patch for 4 hours to intact skin of the flank. Animals
were then observed for 7 days. Irritation was scored by the method of
Draize at 1, 24, 48 and 72 hours and 7 days after exposure.
Mean individual scores at 24, 48 and 72 h after exposure for the 3
animals were 2, 2, 2 for erythema score and 1.33, 2, 1.33 for oedema
score. Signs of erythema and oedema, as well as desquamation from skin
surface, were observed in all animals on Day 7. In this study,
d-limonene was found to be skin irritant when applied topically to the
Under the test conditions, d-limonene is considered irritating to
skin but the effects are not sufficient for classification according to
CLP Regulation (EC) N° 1272/2008.
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